Platinum in PDB 8yu3: uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex

The binding sites of Platinum atom in the uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex (pdb code 8yu3). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex, PDB code: 8yu3:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt101 b:0.2 occ:1.00 PT A:H9C101 0.0 0.2 1.0 N4 A:H9C101 2.2 0.3 1.0 N1 A:H9C101 2.2 0.2 1.0 N3 A:H9C101 2.2 0.3 1.0 N2 A:H9C101 2.2 0.2 1.0 C12 A:H9C101 3.0 0.2 1.0 C11 A:H9C101 3.0 0.2 1.0 C23 A:H9C101 3.0 0.3 1.0 C24 A:H9C101 3.0 0.3 1.0 C22 A:H9C101 3.3 0.3 1.0 C10 A:H9C101 3.3 0.3 1.0 C13 A:H9C101 3.3 0.3 1.0 C1 A:H9C101 3.3 0.2 1.0 H10 A:H9C101 3.4 0.3 1.0 H22 A:H9C101 3.4 0.3 1.0 H13 A:H9C101 3.4 0.3 1.0 H1 A:H9C101 3.4 0.2 1.0 H62 A:DA2 4.0 0.7 1.0 O6 A:DG7 4.4 0.3 1.0 C7 A:H9C101 4.4 0.3 1.0 C19 A:H9C101 4.4 0.3 1.0 C16 A:H9C101 4.4 0.3 1.0 C4 A:H9C101 4.4 0.2 1.0 C9 A:H9C101 4.6 0.3 1.0 C21 A:H9C101 4.6 0.3 1.0 C14 A:H9C101 4.6 0.3 1.0 O6 A:DG16 4.6 0.3 1.0 C2 A:H9C101 4.6 0.2 1.0 H3 A:DT1 4.6 0.7 1.0 O6 A:DG3 4.6 0.3 1.0 H1 A:DG16 4.7 0.3 1.0 N6 A:DA2 4.7 0.6 1.0 O6 A:DG14 4.8 0.2 1.0 N7 A:DA2 4.9 0.6 1.0 H1 A:DG7 5.0 0.3 1.0 H1 A:DG14 5.0 0.2 1.0

Platinum binding site 2 out of 2 in the uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of uc(Nmr) Solution Structure of the 2:1 Complex of A Platinum(II) Compound Bound to MYC1234 G-Quadruplex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt102 b:0.2 occ:1.00 PT A:H9C102 0.0 0.2 1.0 N1 A:H9C102 2.2 0.2 1.0 N3 A:H9C102 2.2 0.2 1.0 N4 A:H9C102 2.2 0.2 1.0 N2 A:H9C102 2.2 0.2 1.0 C11 A:H9C102 3.0 0.2 1.0 C12 A:H9C102 3.0 0.2 1.0 C23 A:H9C102 3.0 0.3 1.0 C24 A:H9C102 3.0 0.2 1.0 C10 A:H9C102 3.3 0.2 1.0 C13 A:H9C102 3.3 0.2 1.0 C22 A:H9C102 3.3 0.3 1.0 C1 A:H9C102 3.3 0.2 1.0 H13 A:H9C102 3.4 0.2 1.0 H10 A:H9C102 3.4 0.3 1.0 H22 A:H9C102 3.4 0.3 1.0 H1 A:H9C102 3.4 0.2 1.0 O6 A:DG5 3.8 0.3 1.0 O6 A:DG18 4.0 0.3 1.0 C7 A:H9C102 4.4 0.2 1.0 C4 A:H9C102 4.4 0.2 1.0 C16 A:H9C102 4.4 0.3 1.0 C19 A:H9C102 4.4 0.3 1.0 O6 A:DG12 4.4 0.3 1.0 C6 A:DG5 4.4 0.3 1.0 H72 A:DT19 4.5 0.8 1.0 C6 A:DG18 4.5 0.3 1.0 H1 A:DG18 4.5 0.3 1.0 C9 A:H9C102 4.5 0.3 1.0 C14 A:H9C102 4.6 0.3 1.0 C21 A:H9C102 4.6 0.3 1.0 C2 A:H9C102 4.6 0.2 1.0 H73 A:DT19 4.6 0.9 1.0 H3 A:DT10 4.6 0.5 1.0 H1 A:DG5 4.8 0.3 1.0 N1 A:DG18 4.8 0.3 1.0 O6 A:DG9 4.8 0.3 1.0 H1 A:DG12 4.8 0.3 1.0 N1 A:DG5 4.9 0.3 1.0 C7 A:DT19 5.0 0.7 1.0

W.Liu, B.C.Zhu, L.Y.Liu, X.Y.Xia, J.Jang, J.Dickerhoff, D.Yang, Z.W.Mao. Solution Structures and Effects of A Platinum Compound Successively Bound Myc G-Quadruplex. Nucleic Acids Res. V. 52 9397 2024.
ISSN: ESSN 1362-4962
PubMed: 39077944
DOI: 10.1093/NAR/GKAE649