Platinum in the structure of uc(Nmr) Solution Structure Of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, The Major Adduct of the Anticancer Drug Cisplatin, 1 Structure (pdb 1a84)

The binding sites of Platinum atom in the structure of uc(Nmr) Solution Structure Of A Dna Dodecamer Duplex Containing A Cis- Diammineplatinum(II) D(Gpg) Intrastrand Cross-Link, The Major Adduct of the Anticancer Drug Cisplatin, 1 Structure (pdb code 1a84). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 1a84 structure was solved by A.GELASCO, S.J.LIPPARD, with NMR in Solution technique. Platinum Binding Sites: Platinum binding site 1 out of 1 in 1a84 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 1a84. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Dt5, A: Dg6, A: Dg7, B: Dc18, A: Cpt13, conact list: Atom Atom Distance (A) Pt H71 A:Dt5 4.68 Pt N9 A:Dg6 4.15 Pt C8 A:Dg6 2.95 Pt C6 A:Dg6 3.65 Pt C5 A:Dg6 3.09 Pt C4 A:Dg6 4.21 Pt H8 A:Dg6 3.15 Pt N1 A:Dg6 4.99 Pt N7 A:Dg6 2.05 Pt O6 A:Dg6 3.50 Pt N9 A:Dg7 4.14 Pt C8 A:Dg7 2.97 Pt C6 A:Dg7 3.62 Pt C5 A:Dg7 3.08 Pt C4 A:Dg7 4.20 Pt H8 A:Dg7 3.22 Pt N1 A:Dg7 4.96 Pt N7 A:Dg7 2.05 Pt O6 A:Dg7 3.47 Pt H41 B:Dc18 4.92 Pt N1 A:Cpt13 2.05 Pt N2 A:Cpt13 2.05 Pt H13 A:Cpt13 2.57 Pt PT1 A:Cpt13 0.00 Pt H23 A:Cpt13 2.57 Pt H21 A:Cpt13 2.57 Pt H22 A:Cpt13 2.57 Pt H11 A:Cpt13 2.57 Pt H12 A:Cpt13 2.57 interactive model: