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Platinum in PDB 1aio: Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin

Protein crystallography data

The structure of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin, PDB code: 1aio was solved by P.M.Takahara, A.C.Rosenzweig, C.A.Frederick, S.J.Lippard, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 8.00 / 2.60
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 31.270, 35.460, 47.010, 79.81, 84.75, 82.79
R / Rfree (%) 20.6 / 25.1

Other elements in 1aio:

The structure of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin also contains other interesting chemical elements:

Bromine (Br) 2 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin (pdb code 1aio). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin, PDB code: 1aio:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 1aio

Go back to Platinum Binding Sites List in 1aio
Platinum binding site 1 out of 2 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt49

b:23.8
occ:1.00
PT1 A:CPT49 0.0 23.8 1.0
N7 A:DG6 1.9 17.7 1.0
N1 A:CPT49 1.9 22.6 1.0
N2 A:CPT49 1.9 22.5 1.0
N7 A:DG7 1.9 23.6 1.0
C8 A:DG7 2.4 23.3 1.0
C8 A:DG6 2.7 17.9 1.0
C5 A:DG6 2.9 18.2 1.0
C5 A:DG7 3.3 24.6 1.0
O6 A:DG6 3.5 18.9 1.0
C6 A:DG6 3.6 18.1 1.0
N9 A:DG7 3.8 23.4 1.0
N9 A:DG6 3.9 18.6 1.0
C4 A:DG6 4.0 18.4 1.0
OP2 A:DG6 4.1 18.5 1.0
C4 A:DG7 4.2 24.0 1.0
C6 A:DG7 4.2 25.9 1.0
O6 A:DG7 4.3 27.7 1.0
N1 A:DG6 4.9 17.4 1.0
O5' A:DG6 4.9 19.6 1.0
N3 A:DT5 5.0 15.3 1.0
C4 A:DT5 5.0 16.2 1.0

Platinum binding site 2 out of 2 in 1aio

Go back to Platinum Binding Sites List in 1aio
Platinum binding site 2 out of 2 in the Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of A Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Pt50

b:26.5
occ:1.00
PT1 C:CPT50 0.0 26.5 1.0
N1 C:CPT50 1.9 24.7 1.0
N7 C:DG31 1.9 19.6 1.0
N7 C:DG30 1.9 12.3 1.0
N2 C:CPT50 1.9 24.5 1.0
C8 C:DG31 2.5 19.4 1.0
C8 C:DG30 2.7 12.2 1.0
C5 C:DG30 3.0 12.1 1.0
C5 C:DG31 3.2 19.5 1.0
O6 C:DG30 3.6 13.2 1.0
C6 C:DG30 3.7 12.3 1.0
N9 C:DG31 3.8 19.7 1.0
N9 C:DG30 3.9 14.0 1.0
C4 C:DG30 4.0 12.4 1.0
C6 C:DG31 4.1 19.6 1.0
C4 C:DG31 4.1 19.1 1.0
O6 C:DG31 4.2 21.0 1.0
OP2 C:DG30 4.3 20.8 1.0
O5' C:DG30 4.9 21.5 1.0
N1 C:DG30 4.9 11.1 1.0
C4 C:DT29 5.0 16.6 1.0

Reference:

P.M.Takahara, A.C.Rosenzweig, C.A.Frederick, S.J.Lippard. Crystal Structure of Double-Stranded Dna Containing the Major Adduct of the Anticancer Drug Cisplatin. Nature V. 377 649 1995.
ISSN: ISSN 0028-0836
PubMed: 7566180
DOI: 10.1038/377649A0
Page generated: Wed Dec 16 02:03:33 2020

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