Platinum in the structure of The Crystal Structure Of The Human Dna Repair Endonuclease HAP1 Suggests the Recognition of Extra-Helical Deoxyribose At Dna Abasic Sites (pdb 1bix)

The binding sites of Platinum atom in the structure of The Crystal Structure Of The Human Dna Repair Endonuclease HAP1 Suggests the Recognition of Extra-Helical Deoxyribose At Dna Abasic Sites (pdb code 1bix). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 1bix structure was solved by M.A.GORMAN, S.MORERA, D.G.ROTHWELL, E.DE LA FORTELLE, C.D.MOL, J.A.TAINER, I.D.HICKSON, P.S.FREEMONT, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 20.0-2.2 Space group C121 a (A) 87.260 b (A) 44.701 c (A) 78.778 alpha (°) 90.00 beta (°) 103.45 gamma (°) 90.00 Rfactor (%) 18.4 Rfree (%) 26.9 Platinum Binding Sites: Platinum binding site 1 out of 1 in 1bix Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 1bix. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Met271, A: Lys276, conact list: Atom Atom Distance (A) Pt O A:Met271 3.96 Pt CB A:Met271 3.45 Pt CE A:Met271 3.32 Pt C A:Met271 4.76 Pt CG A:Met271 2.84 Pt SD A:Met271 1.97 Pt CA A:Met271 4.73 Pt CE A:Lys276 3.38 Pt CD A:Lys276 4.61 Pt NZ A:Lys276 2.92 interactive model: