Platinum in the structure of Solution Structure of A Dna Duplex Containing the Cis-Pt(NH3)2[D(-Gtg- )-N7-(G)-N7(G)N7(G)]Adduct As Determined With High Field uc(Nmr) and Molecular Mechanics/Dynamics (pdb 1da4)

The binding sites of Platinum atom in the structure of Solution Structure of A Dna Duplex Containing the Cis-Pt(NH3)2[D(-Gtg- )-N7-(G)-N7(G)N7(G)]Adduct As Determined With High Field uc(Nmr) and Molecular Mechanics/Dynamics (pdb code 1da4). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 1da4 structure was solved by C.J.VAN GARDEREN, L.P.A.VAN HOUTE, with NMR in Solution technique. Platinum Binding Sites: Platinum binding site 1 out of 1 in 1da4 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 1da4. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Dg6, A: Dt7, A: Dg8, A: Cpt14, A: Dg6, A: Dt7, A: Dg8, A: Cpt14, conact list: Atom Atom Distance (A) Pt N9 A:Dg6 3.93 Pt C8 A:Dg6 2.63 Pt C6 A:Dg6 3.97 Pt C5 A:Dg6 3.18 Pt C4 A:Dg6 4.16 Pt H8 A:Dg6 2.64 Pt N7 A:Dg6 1.97 Pt H2' A:Dg6 4.72 Pt O6 A:Dg6 4.00 Pt H72 A:Dt7 4.28 Pt H2' A:Dt7 4.69 Pt H6 A:Dt7 4.62 Pt N9 A:Dg8 4.22 Pt C8 A:Dg8 2.89 Pt C6 A:Dg8 4.20 Pt C5 A:Dg8 3.45 Pt C4 A:Dg8 4.45 Pt H8 A:Dg8 2.90 Pt N7 A:Dg8 2.17 Pt O6 A:Dg8 4.16 Pt N1 A:Cpt14 2.14 Pt N2 A:Cpt14 1.96 Pt H13 A:Cpt14 2.59 Pt PT1 A:Cpt14 0.00 Pt H23 A:Cpt14 2.55 Pt H21 A:Cpt14 2.26 Pt H22 A:Cpt14 2.47 Pt H11 A:Cpt14 2.83 Pt H12 A:Cpt14 2.63 Pt N9 A:Dg6 3.93 Pt C8 A:Dg6 2.63 Pt C6 A:Dg6 3.97 Pt C5 A:Dg6 3.18 Pt C4 A:Dg6 4.16 Pt H8 A:Dg6 2.64 Pt N7 A:Dg6 1.97 Pt H2' A:Dg6 4.72 Pt O6 A:Dg6 4.00 Pt H72 A:Dt7 4.28 Pt H2' A:Dt7 4.69 Pt H6 A:Dt7 4.62 Pt N9 A:Dg8 4.22 Pt C8 A:Dg8 2.89 Pt C6 A:Dg8 4.20 Pt C5 A:Dg8 3.45 Pt C4 A:Dg8 4.45 Pt H8 A:Dg8 2.90 Pt N7 A:Dg8 2.17 Pt O6 A:Dg8 4.16 Pt N1 A:Cpt14 2.14 Pt N2 A:Cpt14 1.96 Pt H13 A:Cpt14 2.59 Pt PT1 A:Cpt14 0.00 Pt H23 A:Cpt14 2.55 Pt H21 A:Cpt14 2.26 Pt H22 A:Cpt14 2.47 Pt H11 A:Cpt14 2.83 Pt H12 A:Cpt14 2.63 interactive model: