Platinum in the structure of 2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(Ammine)(Cyclohexylamine)}2+ Bound to A Dodecamer Dna Duplex (pdb 1lu5)

The binding sites of Platinum atom in the structure of 2.4 Angstrom Crystal Structure of the Asymmetric Platinum Complex {Pt(Ammine)(Cyclohexylamine)}2+ Bound to A Dodecamer Dna Duplex (pdb code 1lu5). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 1lu5 structure was solved by A.P.SILVERMAN, W.BU, S.M.COHEN, S.J.LIPPARD, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 50.0-2.4 Space group P1 a (A) 31.644 b (A) 35.638 c (A) 46.556 alpha (°) 79.53 beta (°) 83.02 gamma (°) 81.36 Rfactor (%) 23.4 Rfree (%) 29.4 Platinum Binding Sites: Platinum binding site 1 out of 2 in 1lu5 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 1lu5. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Dt5, A: Dg6, A: Dg7, A: Lpt49, A: Hoh204, A: Hoh222, A: Hoh224, conact list: Atom Atom Distance (A) Pt N3 A:Dt5 4.96 Pt C4 A:Dt5 4.88 Pt N9 A:Dg6 3.96 Pt C8 A:Dg6 2.85 Pt C6 A:Dg6 3.53 Pt N1 A:Dg6 4.82 Pt C5 A:Dg6 2.93 Pt N7 A:Dg6 1.97 Pt C4 A:Dg6 4.00 Pt OP2 A:Dg6 4.08 Pt O6 A:Dg6 3.45 Pt N9 A:Dg7 4.11 Pt C8 A:Dg7 2.93 Pt C6 A:Dg7 3.54 Pt N1 A:Dg7 4.89 Pt C5 A:Dg7 2.99 Pt N7 A:Dg7 1.96 Pt C4 A:Dg7 4.14 Pt O6 A:Dg7 3.38 Pt N1 A:Lpt49 2.01 Pt C5 A:Lpt49 4.48 Pt N2 A:Lpt49 2.05 Pt C4 A:Lpt49 3.03 Pt C3 A:Lpt49 3.00 Pt PT A:Lpt49 0.00 Pt C8 A:Lpt49 4.27 Pt O A:Hoh204 3.86 Pt O A:Hoh222 4.41 Pt O A:Hoh224 3.27 interactive model: Platinum binding site 2 out of 2 in 1lu5 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Platinum in the PDB 1lu5. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: C: Dt29, C: Dg30, C: Dg31, C: Lpt50, C: Hoh201, conact list: Atom Atom Distance (A) Pt N3 C:Dt29 4.98 Pt C4 C:Dt29 4.92 Pt N9 C:Dg30 4.02 Pt C8 C:Dg30 2.94 Pt C6 C:Dg30 3.35 Pt N1 C:Dg30 4.67 Pt C5 C:Dg30 2.84 Pt N7 C:Dg30 1.96 Pt C4 C:Dg30 3.97 Pt OP2 C:Dg30 3.99 Pt O6 C:Dg30 3.22 Pt N9 C:Dg31 4.01 Pt C8 C:Dg31 2.85 Pt C6 C:Dg31 3.63 Pt N1 C:Dg31 4.95 Pt C5 C:Dg31 3.00 Pt N7 C:Dg31 1.96 Pt C4 C:Dg31 4.09 Pt O6 C:Dg31 3.56 Pt N1 C:Lpt50 2.01 Pt C5 C:Lpt50 4.55 Pt N2 C:Lpt50 2.05 Pt C4 C:Lpt50 3.06 Pt C3 C:Lpt50 3.05 Pt PT C:Lpt50 0.00 Pt C8 C:Lpt50 4.19 Pt O C:Hoh201 3.60 interactive model: