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Platinum in PDB 1mox: Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha

Enzymatic activity of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha

All present enzymatic activity of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha:
2.7.1.112;

Protein crystallography data

The structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha, PDB code: 1mox was solved by T.P.J.Garrett, N.M.Mckern, M.Lou, T.C.Elleman, T.E.Adams, G.O.Lovrecz, H.-J.Zhu, F.Walker, M.J.Frenkel, P.A.Hoyne, R.N.Jorissen, E.C.Nice, A.W.Burgess, C.W.Ward, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 20.00 / 2.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 51.590, 198.710, 78.900, 90.00, 102.03, 90.00
R / Rfree (%) 23.7 / 28.9

Other elements in 1mox:

The structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha also contains other interesting chemical elements:

Cadmium (Cd) 11 atoms
Chlorine (Cl) 4 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha (pdb code 1mox). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 7 binding sites of Platinum where determined in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha, PDB code: 1mox:
Jump to Platinum binding site number: 1; 2; 3; 4; 5; 6; 7;

Platinum binding site 1 out of 7 in 1mox

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Platinum binding site 1 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt711

b:74.8
occ:0.60
 SD A:MET30 2.3 55.1 1.0
O A:HOH801 2.4 22.0 1.0
CE A:MET30 2.6 52.7 1.0
CG A:MET30 2.8 51.7 1.0
CB A:MET30 4.3 51.7 1.0
CD1 C:LEU49 4.5 62.0 1.0
O A:HOH805 4.7 51.1 1.0
OG A:SER26 4.9 43.8 1.0

Platinum binding site 2 out of 7 in 1mox

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Platinum binding site 2 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt716

b:0.7
occ:0.50
 CE A:MET154 2.4 0.7 1.0
SD A:MET154 2.8 0.9 1.0
CE A:MET152 3.4 0.1 1.0
CG A:MET154 3.6 0.1 1.0
SD A:MET152 3.8 0.5 1.0
CD1 A:TRP140 4.0 43.3 1.0
CB A:MET152 4.1 0.8 1.0
CG A:TRP140 4.5 44.2 1.0
CG A:MET152 4.6 0.7 1.0
CB A:TRP140 4.6 47.5 1.0
CB A:MET154 4.8 0.2 1.0
NE1 A:TRP140 4.8 40.8 1.0

Platinum binding site 3 out of 7 in 1mox

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Platinum binding site 3 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt719

b:1.0
occ:0.20
 SD A:MET294 2.5 0.2 1.0
CG A:MET294 3.7 0.7 1.0
OH A:TYR292 3.7 0.0 1.0
CE A:MET294 4.1 0.6 1.0
CB A:MET294 4.2 0.8 1.0
CZ A:TYR292 4.6 0.1 1.0
CE1 A:TYR292 4.9 0.4 1.0

Platinum binding site 4 out of 7 in 1mox

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Platinum binding site 4 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pt702

b:58.2
occ:0.50
 CE B:MET244 1.5 40.1 1.0
SD B:MET244 1.5 47.1 1.0
NE2 A:HIS280 3.0 66.9 1.0
CG B:MET244 3.2 50.7 1.0
CE1 A:HIS280 3.6 67.9 1.0
CD2 A:HIS280 4.1 67.9 1.0
CB B:MET244 4.3 51.0 1.0
ND1 A:HIS280 4.9 67.3 1.0

Platinum binding site 5 out of 7 in 1mox

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Platinum binding site 5 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pt706

b:55.8
occ:0.60
 SD B:MET30 2.0 41.6 1.0
CE B:MET30 2.2 23.7 1.0
CG B:MET30 2.9 38.7 1.0
O B:HOH799 3.1 26.9 1.0
CG2 B:THR10 3.8 34.6 1.0
CB B:MET30 4.0 37.0 1.0
O B:GLY9 4.5 40.4 1.0
CB B:THR10 4.9 36.0 1.0

Platinum binding site 6 out of 7 in 1mox

Go back to Platinum Binding Sites List in 1mox
Platinum binding site 6 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 6 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pt707

b:57.6
occ:0.50
 NE2 B:HIS280 1.6 52.4 1.0
CE A:MET244 2.2 56.6 1.0
SD A:MET244 2.3 61.4 1.0
CE1 B:HIS280 2.4 55.2 1.0
CD2 B:HIS280 2.8 55.0 1.0
ND1 B:HIS280 3.5 54.2 1.0
CG A:MET244 3.5 57.1 1.0
CG B:HIS280 3.7 54.5 1.0
CB A:MET244 4.3 54.7 1.0
O A:ASP279 4.4 71.0 1.0

Platinum binding site 7 out of 7 in 1mox

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Platinum binding site 7 out of 7 in the Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 7 of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex with Tgf-Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pt714

b:0.5
occ:0.50
 CG B:MET154 2.3 0.3 1.0
CB B:MET154 2.4 0.1 1.0
CE B:MET154 2.7 0.2 1.0
SD B:MET152 2.8 1.0 1.0
SD B:MET154 3.0 0.3 1.0
CD1 B:TRP140 3.7 64.1 1.0
CG B:MET152 3.7 0.2 1.0
CA B:MET154 3.8 0.5 1.0
N B:MET154 4.2 0.1 1.0
CE B:MET152 4.2 0.6 1.0
NE1 B:TRP140 4.3 65.0 1.0
CG B:TRP140 4.5 64.2 1.0
CE1 B:PHE156 4.6 0.5 1.0
CZ B:PHE156 4.7 0.8 1.0
C B:MET154 4.8 0.9 1.0
CB B:TRP140 4.9 63.5 1.0

Reference:

T.P.J.Garrett, N.M.Mckern, M.Lou, T.C.Elleman, T.E.Adams, G.O.Lovrecz, H.-J.Zhu, F.Walker, M.J.Frenkel, P.A.Hoyne, R.N.Jorissen, E.C.Nice, A.W.Burgess, C.W.Ward. Crystal Structure of A Truncated Epidermal Growth Factor Receptor Extracellular Domain Bound to Transforming Growth Factor Alpha Cell(Cambridge,Mass.) V. 110 763 2002.
ISSN: ISSN 0092-8674
PubMed: 12297049
DOI: 10.1016/S0092-8674(02)00940-6
Page generated: Thu Oct 10 10:35:49 2024

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