Platinum in the structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex With Tgf-Alpha (pdb 1mox)

The binding sites of Platinum atom in the structure of Crystal Structure of Human Epidermal Growth Factor Receptor (Residues 1-501) in Complex With Tgf-Alpha (pdb code 1mox). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 1mox structure was solved by T.P.J.GARRETT, N.M.MCKERN, M.LOU, T.C.ELLEMAN, T.E.ADAMS, G.O.LOVRECZ, H.-J.ZHU, F.WALKER, M.J.FRENKEL, P.A.HOYNE, R.N.JORISSEN, E.C.NICE, A.W.BURGESS, C.W.WARD, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 20.0-2.5 Space group P1211 a (A) 51.590 b (A) 198.710 c (A) 78.900 alpha (°) 90.00 beta (°) 102.03 gamma (°) 90.00 Rfactor (%) 23.7 Rfree (%) 28.9 Platinum Binding Sites: Platinum binding site 1 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Ser26, A: Met30, C: Leu49, A: Hoh801, A: Hoh805, conact list: Atom Atom Distance (A) Pt OG A:Ser26 4.88 Pt CB A:Met30 4.29 Pt CE A:Met30 2.58 Pt CG A:Met30 2.78 Pt SD A:Met30 2.30 Pt CD1 C:Leu49 4.54 Pt O A:Hoh801 2.37 Pt O A:Hoh805 4.70 interactive model: Platinum binding site 2 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Trp140, A: Met152, A: Met154, conact list: Atom Atom Distance (A) Pt CB A:Trp140 4.65 Pt CD1 A:Trp140 4.01 Pt CG A:Trp140 4.55 Pt NE1 A:Trp140 4.83 Pt CB A:Met152 4.09 Pt CE A:Met152 3.39 Pt CG A:Met152 4.63 Pt SD A:Met152 3.82 Pt CB A:Met154 4.83 Pt CE A:Met154 2.40 Pt CG A:Met154 3.61 Pt SD A:Met154 2.79 interactive model: Platinum binding site 3 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 3 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Tyr292, A: Met294, conact list: Atom Atom Distance (A) Pt CZ A:Tyr292 4.58 Pt CE1 A:Tyr292 4.94 Pt OH A:Tyr292 3.75 Pt CB A:Met294 4.20 Pt CE A:Met294 4.08 Pt CG A:Met294 3.65 Pt SD A:Met294 2.49 interactive model: Platinum binding site 4 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 4 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: His280, B: Met244, conact list: Atom Atom Distance (A) Pt NE2 A:His280 2.95 Pt ND1 A:His280 4.86 Pt CD2 A:His280 4.10 Pt CE1 A:His280 3.62 Pt CB B:Met244 4.35 Pt CE B:Met244 1.52 Pt CG B:Met244 3.24 Pt SD B:Met244 1.54 interactive model: Platinum binding site 5 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 5 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: B: Gly9, B: Thr10, B: Met30, B: Hoh799, conact list: Atom Atom Distance (A) Pt O B:Gly9 4.50 Pt CB B:Thr10 4.95 Pt CG2 B:Thr10 3.76 Pt CB B:Met30 4.05 Pt CE B:Met30 2.18 Pt CG B:Met30 2.94 Pt SD B:Met30 2.03 Pt O B:Hoh799 3.11 interactive model: Platinum binding site 6 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 6 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Met244, A: Asp279, B: His280, conact list: Atom Atom Distance (A) Pt CB A:Met244 4.27 Pt CE A:Met244 2.22 Pt CG A:Met244 3.53 Pt SD A:Met244 2.32 Pt O A:Asp279 4.41 Pt NE2 B:His280 1.58 Pt ND1 B:His280 3.53 Pt CD2 B:His280 2.77 Pt CE1 B:His280 2.35 Pt CG B:His280 3.74 interactive model: Platinum binding site 7 out of 7 in 1mox Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 7 of Platinum in the PDB 1mox. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: B: Trp140, B: Met152, B: Met154, B: Phe156, conact list: Atom Atom Distance (A) Pt CB B:Trp140 4.90 Pt CD1 B:Trp140 3.68 Pt CG B:Trp140 4.48 Pt NE1 B:Trp140 4.26 Pt CE B:Met152 4.18 Pt CG B:Met152 3.71 Pt SD B:Met152 2.78 Pt N B:Met154 4.16 Pt CB B:Met154 2.35 Pt CE B:Met154 2.71 Pt C B:Met154 4.77 Pt CG B:Met154 2.29 Pt SD B:Met154 2.99 Pt CA B:Met154 3.78 Pt CZ B:Phe156 4.68 Pt CE1 B:Phe156 4.62 interactive model: