Atomistry » Platinum » PDB 1uas-3co3 » 2wtf
Atomistry »
  Platinum »
    PDB 1uas-3co3 »
      2wtf »

Platinum in PDB 2wtf: Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link

Enzymatic activity of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link

All present enzymatic activity of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link:
2.7.7.7;

Protein crystallography data

The structure of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link, PDB code: 2wtf was solved by T.Reissner, S.Schneider, O.Ziv, S.Schorr, Z.Livneh, T.Carell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.00 / 2.50
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 103.240, 103.240, 292.740, 90.00, 90.00, 90.00
R / Rfree (%) 22.712 / 26.871

Other elements in 2wtf:

The structure of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link also contains other interesting chemical elements:

Calcium (Ca) 10 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link (pdb code 2wtf). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link, PDB code: 2wtf:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 2wtf

Go back to Platinum Binding Sites List in 2wtf
Platinum binding site 1 out of 2 in the Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link within 5.0Å range:
probe atom residue distance (Å) B Occ
O:Pt1014

b:55.1
occ:1.00
PT1 O:CPT1014 0.0 55.1 1.0
N1 O:CPT1014 2.0 45.4 1.0
N2 O:CPT1014 2.1 51.7 1.0
N7 O:DG0 2.1 55.3 1.0
N7 O:DG2 2.2 43.6 1.0
C8 O:DG0 3.1 60.5 1.0
C8 O:DG2 3.2 42.3 1.0
C5 O:DG0 3.2 57.7 1.0
C5 O:DG2 3.3 39.2 1.0
O6 O:DG2 3.5 40.5 1.0
O6 O:DG0 3.6 52.9 1.0
C6 O:DG0 3.7 55.4 1.0
C6 O:DG2 3.7 39.4 1.0
N9 O:DG0 4.3 63.9 1.0
C4 O:DG0 4.4 61.0 1.0
N9 O:DG2 4.4 45.4 1.0
C4 O:DG2 4.4 41.0 1.0
N4 O:DC3 4.9 32.7 1.0

Platinum binding site 2 out of 2 in 2wtf

Go back to Platinum Binding Sites List in 2wtf
Platinum binding site 2 out of 2 in the Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Dna Polymerase Eta in Complex with the Cis-Diammineplatinum (II) 1,3-Gtg Intrastrand Cross-Link within 5.0Å range:
probe atom residue distance (Å) B Occ
S:Pt1014

b:68.5
occ:1.00
PT1 S:CPT1014 0.0 68.5 1.0
N2 S:CPT1014 2.1 62.2 1.0
N1 S:CPT1014 2.1 64.0 1.0
N7 S:DG0 2.1 69.5 1.0
N7 S:DG2 2.2 60.8 1.0
C8 S:DG0 2.9 72.4 1.0
C5 S:DG2 3.1 57.8 1.0
C8 S:DG2 3.2 61.4 1.0
O6 S:DG2 3.3 47.2 1.0
C5 S:DG0 3.3 69.9 1.0
O2 S:DT-1 3.5 62.4 1.0
C6 S:DG2 3.5 53.8 1.0
O6 S:DG0 3.8 64.0 1.0
C6 S:DG0 3.9 67.3 1.0
N9 S:DG0 4.2 73.5 1.0
C4 S:DG2 4.3 59.9 1.0
N9 S:DG2 4.3 63.0 1.0
C2 S:DT-1 4.4 63.3 1.0
C4 S:DG0 4.4 71.2 1.0
N3 S:DT-1 4.4 62.3 1.0
N4 S:DC3 4.8 57.2 1.0
O6 T:DG8 4.8 44.4 1.0
N1 S:DG2 4.9 53.6 1.0

Reference:

T.Reissner, S.Schneider, S.Schorr, T.Carell. Crystal Structure of A Cisplatin-(1,3-Gtg) Cross- Link Within Dna Polymerase Eta. Angew.Chem.Int.Ed.Engl. V. 49 3077 2010.
ISSN: ISSN 1433-7851
PubMed: 20333640
DOI: 10.1002/ANIE.201000414
Page generated: Thu Oct 10 10:44:39 2024

Last articles

Zn in 7WU0
Zn in 7WTZ
Zn in 7WTX
Zn in 7WTW
Zn in 7WT5
Zn in 7WTU
Zn in 7WTV
Zn in 7WTT
Zn in 7WT4
Zn in 7WT3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy