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Platinum in PDB 2zzb: Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II)

Enzymatic activity of Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II)

All present enzymatic activity of Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II):
1.8.1.9;

Protein crystallography data

The structure of Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II), PDB code: 2zzb was solved by Y.C.Lo, T.P.Ko, A.H.J.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.20
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 120.947, 135.165, 346.037, 90.00, 90.00, 90.00
R / Rfree (%) 24.2 / 30.5

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II) (pdb code 2zzb). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II), PDB code: 2zzb:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 2zzb

Go back to Platinum Binding Sites List in 2zzb
Platinum binding site 1 out of 2 in the Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Pt501

b:29.4
occ:0.50
PT1 B:TPT501 0.0 29.4 0.5
N2 B:TPT501 2.0 31.4 0.5
N3 B:TPT501 2.0 33.8 0.5
N1 B:TPT501 2.1 33.9 0.5
C11 B:TPT501 2.9 35.1 0.5
C10 B:TPT501 2.9 34.4 0.5
C5 B:TPT501 2.9 35.3 0.5
C6 B:TPT501 2.9 34.4 0.5
C15 B:TPT501 3.0 36.9 0.5
C1 B:TPT501 3.0 37.0 0.5
CB B:TRP114 4.1 38.9 1.0
C12 B:TPT501 4.2 37.4 0.5
C9 B:TPT501 4.2 37.0 0.5
C7 B:TPT501 4.3 36.8 0.5
C4 B:TPT501 4.3 37.7 0.5
C14 B:TPT501 4.3 38.4 0.5
C2 B:TPT501 4.3 38.5 0.5
CG B:TRP114 4.6 48.3 1.0
C8 B:TPT501 4.8 38.8 0.5
CA B:SER111 4.8 29.3 1.0
C13 B:TPT501 4.8 39.0 0.5
C3 B:TPT501 4.8 39.2 0.5
CD1 B:TRP114 4.9 51.8 1.0

Platinum binding site 2 out of 2 in 2zzb

Go back to Platinum Binding Sites List in 2zzb
Platinum binding site 2 out of 2 in the Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of Human Thioredoxin Reductase I and Terpyridine Platinum(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Pt501

b:42.2
occ:0.50
PT1 D:TPT501 0.0 42.2 0.5
N2 D:TPT501 2.0 43.5 0.5
N3 D:TPT501 2.0 45.5 0.5
N1 D:TPT501 2.1 45.4 0.5
SG C:CYS498 2.2 0.7 1.0
C11 D:TPT501 2.9 46.1 0.5
C10 D:TPT501 2.9 44.7 0.5
C5 D:TPT501 2.9 46.0 0.5
C6 D:TPT501 2.9 44.6 0.5
C15 D:TPT501 3.0 46.5 0.5
C1 D:TPT501 3.0 46.5 0.5
CB C:CYS498 3.5 0.8 1.0
C12 D:TPT501 4.2 47.4 0.5
C9 D:TPT501 4.2 46.6 0.5
C7 D:TPT501 4.3 46.7 0.5
C4 D:TPT501 4.3 47.3 0.5
C14 D:TPT501 4.3 47.8 0.5
CB D:TRP114 4.3 57.9 1.0
C2 D:TPT501 4.3 47.9 0.5
CA C:CYS498 4.7 0.7 1.0
C8 D:TPT501 4.8 48.2 0.5
C13 D:TPT501 4.8 48.6 0.5
C3 D:TPT501 4.8 48.6 0.5
CG D:TRP114 4.9 66.7 1.0
CA D:SER111 4.9 39.6 1.0

Reference:

Y.C.Lo, T.P.Ko, W.C.Su, T.L.Su, A.H.J.Wang. Terpyridine-Platinum(II) Complexes Are Effective Inhibitors of Mammalian Topoisomerases and Human Thioredoxin Reductase 1. J.Inorg.Biochem. V. 103 1082 2009.
ISSN: ISSN 0162-0134
PubMed: 19525010
DOI: 10.1016/J.JINORGBIO.2009.05.006
Page generated: Wed Dec 16 02:04:08 2020

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