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Platinum in PDB 3iwx: Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer)

Protein crystallography data

The structure of Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer), PDB code: 3iwx was solved by A.K.Boal, A.C.Rosenzweig, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.76 / 2.14
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 78.289, 78.289, 54.335, 90.00, 90.00, 120.00
R / Rfree (%) 18.6 / 22.8

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) (pdb code 3iwx). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer), PDB code: 3iwx:

Platinum binding site 1 out of 1 in 3iwx

Go back to Platinum Binding Sites List in 3iwx
Platinum binding site 1 out of 1 in the Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Cisplatin Bound to A Human Copper Chaperone (Dimer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt69

b:37.2
occ:0.40
PT1 A:CPT69 0.0 37.2 0.4
N2 A:CPT69 1.8 63.9 0.4
N1 A:CPT69 2.0 64.1 0.4
SG B:CYS15 2.1 19.7 1.0
SG A:CYS15 2.3 24.4 1.0
SG B:CYS12 2.5 23.0 1.0
SG A:CYS12 2.5 26.0 1.0
CB B:CYS15 3.5 16.6 1.0
N B:CYS15 3.5 16.4 1.0
CB A:CYS12 3.6 23.9 1.0
CB A:CYS15 3.6 21.7 1.0
N A:CYS15 3.6 21.4 1.0
CB B:CYS12 3.7 19.9 1.0
N B:CYS12 3.9 20.6 1.0
CA B:CYS15 3.9 16.8 1.0
CA A:CYS15 4.0 22.2 1.0
N A:CYS12 4.1 23.8 1.0
CA B:CYS12 4.2 20.0 1.0
O B:HOH134 4.3 34.5 1.0
OG1 B:THR11 4.3 22.9 1.0
C B:GLY14 4.3 16.8 1.0
CA A:CYS12 4.3 23.4 1.0
OG1 A:THR11 4.5 24.0 1.0
O B:CYS12 4.5 17.9 1.0
C A:GLY14 4.5 21.2 1.0
C B:CYS12 4.5 18.4 1.0
CA B:GLY14 4.6 16.6 1.0
O A:CYS12 4.7 22.1 1.0
C A:CYS12 4.7 22.7 1.0
C A:THR11 4.7 23.9 1.0
CA A:GLY14 4.8 21.1 1.0
N B:GLY14 4.8 16.5 1.0
C B:THR11 4.8 21.1 1.0
N B:THR11 4.9 20.8 1.0
N A:GLY14 5.0 20.8 1.0

Reference:

A.K.Boal, A.C.Rosenzweig. Crystal Structures of Cisplatin Bound to A Human Copper Chaperone. J.Am.Chem.Soc. V. 131 14196 2009.
ISSN: ISSN 0002-7863
PubMed: 19807176
DOI: 10.1021/JA906363T
Page generated: Wed Dec 16 02:04:13 2020

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