Platinum in PDB 3m9m: Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion

Enzymatic activity of Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion

All present enzymatic activity of Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion:
2.7.7.7;

Protein crystallography data

The structure of Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion, PDB code: 3m9m was solved by J.H.Y.Wong, H.Ling, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	45.00 / 2.90
*Space group*	P 2₁ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	98.576, 101.193, 52.418, 90.00, 90.00, 90.00
*R / R_free (%)*	28.5 / 30.9

Other elements in 3m9m:

The structure of Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion also contains other interesting chemical elements:

Calcium

(Ca)

4 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion (pdb code 3m9m). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion, PDB code: 3m9m:

Platinum binding site 1 out of 1 in 3m9m

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Platinum Binding Sites List in 3m9m

Platinum binding site 1 out of 1 in the Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of DPO4 in Complex with Dna Containing the Major Cisplatin Lesion within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
T:Pt1004 b:99.5 occ:1.00	PT1	T:CPT1004	0.0	99.5	1.0
	N2	T:CPT1004	1.9	90.1	1.0
	N7	T:DG4	1.9	88.8	1.0
	N1	T:CPT1004	2.0	91.4	1.0
	N7	T:DG3	2.0	92.5	1.0
	C8	T:DG3	2.6	92.0	1.0
	C8	T:DG4	2.9	88.2	1.0
	C5	T:DG4	3.0	84.9	1.0
	C5	T:DG3	3.2	90.8	1.0
	O6	T:DG4	3.3	81.2	1.0
	C6	T:DG4	3.5	82.3	1.0
	O6	T:DG3	3.8	90.8	1.0
	N9	T:DG3	3.9	90.2	1.0
	C6	T:DG3	3.9	89.9	1.0
	C4	T:DG3	4.2	90.1	1.0
	N9	T:DG4	4.2	85.1	1.0
	C4	T:DG4	4.2	83.9	1.0
	N1	T:DG4	4.9	80.9	1.0
	O	T:HOH84	4.9	57.0	1.0

Reference:

J.H.Wong, J.A.Brown, Z.Suo, P.Blum, T.Nohmi, H.Ling. Structural Insight Into Dynamic Bypass of the Major Cisplatin-Dna Adduct By Y-Family Polymerase DPO4. Embo J. V. 29 2059 2010.
ISSN: ISSN 0261-4189
PubMed: 20512114
DOI: 10.1038/EMBOJ.2010.101

Page generated: Thu Oct 10 10:47:52 2024

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