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Platinum in PDB 3n9j: Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin
Enzymatic activity of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin
All present enzymatic activity of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin:
2.5.1.18;
2.5.1.18;
Protein crystallography data
The structure of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin, PDB code: 3n9j
was solved by
L.J.Parker,
M.W.Parker,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.28 / 1.85 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 76.806, 89.994, 68.870, 90.00, 98.24, 90.00 |
| R / Rfree (%) | 17.8 / 21.8 |
Other elements in 3n9j:
The structure of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin also contains other interesting chemical elements:
| Chlorine | (Cl) | 5 atoms |
| Calcium | (Ca) | 3 atoms |
Platinum Binding Sites:
The binding sites of Platinum atom in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin
(pdb code 3n9j). This binding sites where shown within
5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin, PDB code: 3n9j:
In total only one binding site of Platinum was determined in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin, PDB code: 3n9j:
Platinum binding site 1 out of 1 in 3n9j
Go back to
Platinum Binding Sites List in 3n9j
Platinum binding site 1 out
of 1 in the Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Platinum with other atoms in the Pt binding
site number 1 of Structure of Human Glutathione Transferase Pi Class in Complex with Ethacraplatin within 5.0Å range:
|
Reference:
L.J.Parker,
L.C.Italiano,
C.J.Morton,
N.C.Hancock,
D.B.Ascher,
J.B.Aitken,
H.H.Harris,
P.Campomanes,
U.Rothlisberger,
A.De Luca,
M.Lo Bello,
W.H.Ang,
P.J.Dyson,
M.W.Parker.
Studies of Glutathione Transferase P1-1 Bound to A Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation. To Be Published.
Page generated: Thu Oct 10 10:48:12 2024
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