Platinum in PDB 3txg: Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant

All present enzymatic activity of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant:
3.2.1.17;

The structure of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant, PDB code: 3txg was solved by S.W.M.Tanley, A.M.M.Schreurs, J.R.Helliwell, L.M.J.Kroon-Batenburg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	34.92 / 1.70
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	78.081, 78.081, 37.107, 90.00, 90.00, 90.00
R / Rfree (%)	18.2 / 23.9

The structure of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant also contains other interesting chemical elements:

Chlorine	(Cl)	10 atoms
Sodium	(Na)	1 atom

The binding sites of Platinum atom in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant (pdb code 3txg). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant, PDB code: 3txg:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt130 b:29.1 occ:1.00 PT1 A:CPT130 0.0 29.1 1.0 N1 A:CPT130 2.1 24.5 1.0 NE2 A:HIS15 2.3 19.4 1.0 CL2 A:CPT130 2.4 31.5 1.0 CL1 A:CPT130 2.4 37.9 1.0 NH1 A:ARG14 3.1 26.9 1.0 CD2 A:HIS15 3.2 22.1 1.0 CE1 A:HIS15 3.3 18.1 1.0 O A:HOH2100 4.0 21.7 1.0 CG A:HIS15 4.3 18.3 1.0 CB A:ALA11 4.3 13.2 1.0 ND1 A:HIS15 4.3 21.5 1.0 CZ A:ARG14 4.4 29.5 1.0 CG1 A:ILE88 4.5 14.6 1.0 OG1 A:THR89 4.9 18.6 1.0 CA A:ALA11 4.9 14.0 1.0 O A:ALA11 4.9 13.1 1.0

Platinum binding site 2 out of 2 in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt131 b:37.8 occ:1.00 PT1 A:CPT131 0.0 37.8 1.0 N2 A:CPT131 2.1 31.0 1.0 N1 A:CPT131 2.1 16.8 1.0 ND1 A:HIS15 2.4 21.5 1.0 CL2 A:CPT131 2.4 39.8 1.0 CG A:HIS15 3.2 18.3 1.0 CE1 A:HIS15 3.3 18.1 1.0 CB A:HIS15 3.4 15.4 1.0 CA A:HIS15 3.6 16.3 1.0 O A:HIS15 4.0 17.1 1.0 O A:HOH2101 4.1 23.8 1.0 C A:HIS15 4.3 16.7 1.0 O A:HOH2104 4.3 31.1 1.0 CD2 A:HIS15 4.4 22.1 1.0 NE2 A:HIS15 4.4 19.4 1.0 CG2 A:THR89 4.4 18.1 1.0 N A:HIS15 4.8 15.1 1.0 C2 A:DMS140 4.8 40.1 1.0 OD1 A:ASN93 4.9 31.1 1.0 OG1 A:THR89 4.9 18.6 1.0

S.W.Tanley, A.M.Schreurs, J.R.Helliwell, L.M.Kroon-Batenburg. Experience with Exchange and Archiving of Raw Data: Comparison of Data From Two Diffractometers and Four Software Packages on A Series of Lysozyme Crystals. J.Appl.Crystallogr. V. 46 108 2013.
ISSN: ISSN 0021-8898
PubMed: 23396873
DOI: 10.1107/S0021889812044172