Platinum in PDB 3txk: Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5

All present enzymatic activity of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5:
3.2.1.17;

The structure of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5, PDB code: 3txk was solved by S.W.M.Tanley, A.M.M.Schreurs, J.R.Helliwell, L.M.J.Kroon-Batenburg, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.51 / 3.00
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	79.460, 79.460, 36.960, 90.00, 90.00, 90.00
R / Rfree (%)	21.1 / 25.9

The structure of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5 also contains other interesting chemical elements:

Chlorine	(Cl)	7 atoms
Sodium	(Na)	1 atom

The binding sites of Platinum atom in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5 (pdb code 3txk). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5, PDB code: 3txk:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt133 b:0.6 occ:1.00 PT1 A:CPT133 0.0 0.6 1.0 N1 A:CPT133 2.0 0.1 1.0 N2 A:CPT133 2.0 0.4 1.0 ND1 A:HIS15 2.5 45.2 1.0 CE1 A:HIS15 3.0 46.4 1.0 CG A:HIS15 3.5 45.6 1.0 CA A:HIS15 3.9 45.6 1.0 O A:ARG14 3.9 50.6 1.0 NE2 A:HIS15 4.0 46.5 1.0 CB A:HIS15 4.1 44.1 1.0 CD2 A:HIS15 4.2 46.3 1.0 CG2 A:THR89 4.3 48.8 1.0 C A:HIS15 4.7 44.5 1.0 C A:ARG14 4.8 49.5 1.0 N A:HIS15 4.8 47.1 1.0 O A:HIS15 4.9 43.1 1.0 NH1 A:ARG14 4.9 65.5 1.0

Platinum binding site 2 out of 2 in the Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Hewl Co-Crystallization with Cisplatin in Dmso Media with Paratone As the Cryoprotectant at pH 6.5 within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt134 b:0.6 occ:1.00 PT1 A:CPT134 0.0 0.6 1.0 N2 A:CPT134 2.0 0.4 1.0 N1 A:CPT134 2.0 0.2 1.0 NE2 A:HIS15 2.4 46.5 1.0 CD2 A:HIS15 3.3 46.3 1.0 CE1 A:HIS15 3.4 46.4 1.0 NH1 A:ARG14 3.6 65.5 1.0 OD2 A:ASP87 3.9 52.7 1.0 CG A:HIS15 4.5 45.6 1.0 ND1 A:HIS15 4.5 45.2 1.0 OG1 A:THR89 4.6 48.9 1.0 CZ A:ARG14 4.7 67.6 1.0

S.W.Tanley, A.M.Schreurs, J.R.Helliwell, L.M.Kroon-Batenburg. Experience with Exchange and Archiving of Raw Data: Comparison of Data From Two Diffractometers and Four Software Packages on A Series of Lysozyme Crystals. J.Appl.Crystallogr. V. 46 108 2013.
ISSN: ISSN 0021-8898
PubMed: 23396873
DOI: 10.1107/S0021889812044172