Platinum in the structure of Eval Processed Hewl, Carboplatin Dmso Glycerol (pdb 4dd7)

The binding sites of Platinum atom in the structure of Eval Processed Hewl, Carboplatin Dmso Glycerol (pdb code 4dd7). This binding sites where shown with 5.0 Angstroms radius around Platinum atom. The 4dd7 structure was solved by S.W.TANLEY, A.M.SCHREURS, L.M.KROON-BATENBURG, J.MEREDITH, R.PRENDERGAST, D.WALSH, P.BRYANT, C.LEVY, J.R.HELLIWELL, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 35.2-1.6 Space group P43212 a (A) 78.820 b (A) 78.820 c (A) 37.027 alpha (°) 90.00 beta (°) 90.00 gamma (°) 90.00 Rfactor (%) 18.4 Rfree (%) 22.3 Platinum Binding Sites: Platinum binding site 1 out of 2 in 4dd7 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Platinum in the PDB 4dd7. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Ala11, A: Arg14, A: His15, A: Asp87, A: Ile88, A: Thr89, A: Qpt201, A: Hoh330, conact list: Atom Atom Distance (A) Pt CB A:Ala11 4.99 Pt CD A:Arg14 4.24 Pt CZ A:Arg14 3.62 Pt NE A:Arg14 4.32 Pt NH2 A:Arg14 4.53 Pt NH1 A:Arg14 2.35 Pt NE2 A:His15 2.29 Pt ND1 A:His15 4.35 Pt CD2 A:His15 3.31 Pt CE1 A:His15 3.19 Pt CG A:His15 4.42 Pt OD2 A:Asp87 4.19 Pt OD1 A:Asp87 4.11 Pt CG A:Asp87 4.33 Pt N A:Ile88 4.99 Pt OG1 A:Thr89 4.89 Pt N1 A:Qpt201 2.14 Pt N2 A:Qpt201 2.12 Pt PT1 A:Qpt201 0.00 Pt O A:Hoh330 4.14 interactive model: Platinum binding site 2 out of 2 in 4dd7 Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 2 of Platinum in the PDB 4dd7. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Platinum atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Arg14, A: His15, A: Thr89, A: Qpt202, A: Dms208, A: Hoh347, A: Hoh378, conact list: Atom Atom Distance (A) Pt O A:Arg14 4.82 Pt O A:His15 4.01 Pt NE2 A:His15 4.36 Pt N A:His15 4.74 Pt CB A:His15 3.55 Pt ND1 A:His15 2.28 Pt CD2 A:His15 4.37 Pt C A:His15 4.21 Pt CE1 A:His15 3.24 Pt CG A:His15 3.25 Pt CA A:His15 3.58 Pt CG2 A:Thr89 4.59 Pt OG1 A:Thr89 4.53 Pt N1 A:Qpt202 2.07 Pt N2 A:Qpt202 2.19 Pt PT1 A:Qpt202 0.00 Pt C1 A:Dms208 4.84 Pt O A:Hoh347 4.14 Pt O A:Hoh378 2.31 interactive model: