Atomistry » Platinum » PDB 3wua-4nsi » 4dd9
Atomistry »
  Platinum »
    PDB 3wua-4nsi »
      4dd9 »

Platinum in PDB 4dd9: Eval Processed Hewl, Carboplatin Dmso Paratone

Enzymatic activity of Eval Processed Hewl, Carboplatin Dmso Paratone

All present enzymatic activity of Eval Processed Hewl, Carboplatin Dmso Paratone:
3.2.1.17;

Protein crystallography data

The structure of Eval Processed Hewl, Carboplatin Dmso Paratone, PDB code: 4dd9 was solved by S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.Meredith, R.Prendergast, D.Walsh, P.Bryant, C.Levy, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 39.02 / 1.60
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.041, 78.041, 36.958, 90.00, 90.00, 90.00
R / Rfree (%) 20.4 / 23.6

Platinum Binding Sites:

The binding sites of Platinum atom in the Eval Processed Hewl, Carboplatin Dmso Paratone (pdb code 4dd9). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Eval Processed Hewl, Carboplatin Dmso Paratone, PDB code: 4dd9:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4dd9

Go back to Platinum Binding Sites List in 4dd9
Platinum binding site 1 out of 2 in the Eval Processed Hewl, Carboplatin Dmso Paratone


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Eval Processed Hewl, Carboplatin Dmso Paratone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:36.5
occ:1.00
PT1 A:QPT201 0.0 36.5 1.0
N1 A:QPT201 2.1 25.0 1.0
N2 A:QPT201 2.2 20.2 1.0
NH1 A:ARG14 2.3 28.4 1.0
NE2 A:HIS15 2.3 22.4 1.0
CE1 A:HIS15 3.2 23.3 1.0
CD2 A:HIS15 3.3 23.1 1.0
CZ A:ARG14 3.5 30.3 1.0
OD2 A:ASP87 4.1 33.2 1.0
OD1 A:ASP87 4.2 28.5 1.0
CD A:ARG14 4.3 30.1 1.0
NE A:ARG14 4.3 34.6 1.0
CG A:ASP87 4.3 32.0 1.0
ND1 A:HIS15 4.4 25.4 1.0
NH2 A:ARG14 4.4 36.6 1.0
CG A:HIS15 4.4 23.9 1.0
CB A:ALA11 4.7 18.7 1.0
N A:ILE88 4.9 22.1 1.0
CG1 A:ILE88 4.9 22.1 1.0
OG1 A:THR89 4.9 23.2 1.0

Platinum binding site 2 out of 2 in 4dd9

Go back to Platinum Binding Sites List in 4dd9
Platinum binding site 2 out of 2 in the Eval Processed Hewl, Carboplatin Dmso Paratone


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Eval Processed Hewl, Carboplatin Dmso Paratone within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:41.4
occ:1.00
PT1 A:QPT202 0.0 41.4 1.0
N1 A:QPT202 2.1 32.5 1.0
N2 A:QPT202 2.1 27.4 1.0
ND1 A:HIS15 2.3 25.4 1.0
O A:HOH357 2.4 20.5 1.0
CG A:HIS15 3.2 23.9 1.0
CE1 A:HIS15 3.3 23.3 1.0
CB A:HIS15 3.5 22.8 1.0
CA A:HIS15 3.5 24.1 1.0
O A:HIS15 4.0 25.2 1.0
C A:HIS15 4.2 23.0 1.0
O A:HOH338 4.3 32.1 1.0
CD2 A:HIS15 4.4 23.1 1.0
NE2 A:HIS15 4.4 22.4 1.0
OG1 A:THR89 4.5 23.2 1.0
CG2 A:THR89 4.6 23.0 1.0
N A:HIS15 4.6 25.0 1.0
O A:ARG14 4.8 26.4 1.0
C1 A:DMS213 4.9 90.9 1.0

Reference:

S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.Meredith, R.Prendergast, D.Walsh, P.Bryant, C.Levy, J.R.Helliwell. Structural Studies of the Effect That Dimethyl Sulfoxide (Dmso) Has on Cisplatin and Carboplatin Binding to Histidine in A Protein. Acta Crystallogr.,Sect.D V. 68 601 2012.
ISSN: ISSN 0907-4449
PubMed: 22525758
DOI: 10.1107/S0907444912006907
Page generated: Wed Dec 16 02:04:41 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy