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Atomistry » Platinum » PDB 4dd7-4nsj » 4dl5 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Platinum » PDB 4dd7-4nsj » 4dl5 » |
Platinum in PDB 4dl5: Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).Enzymatic activity of Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).
All present enzymatic activity of Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).:
2.7.7.7; Protein crystallography data
The structure of Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2)., PDB code: 4dl5
was solved by
Y.Zhao,
C.Biertumpfel,
M.Gregory,
F.Hanaoka,
Y.Hua,
W.Yang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4dl5:
The structure of Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2). also contains other interesting chemical elements:
Platinum Binding Sites:
The binding sites of Platinum atom in the Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).
(pdb code 4dl5). This binding sites where shown within
5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2)., PDB code: 4dl5: Jump to Platinum binding site number: 1; 2; Platinum binding site 1 out of 2 in 4dl5Go back to Platinum Binding Sites List in 4dl5
Platinum binding site 1 out
of 2 in the Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).
Mono view Stereo pair view
Platinum binding site 2 out of 2 in 4dl5Go back to Platinum Binding Sites List in 4dl5
Platinum binding site 2 out
of 2 in the Human Dna Polymerase Eta Inserting Dcmpnpp Opposite the 5'G of Cisplatin Crosslinked Gs (Pt-GG2).
Mono view Stereo pair view
Reference:
Y.Zhao,
C.Biertumpfel,
M.T.Gregory,
Y.J.Hua,
F.Hanaoka,
W.Yang.
Structural Basis For Chemoresistance to Cisplatin Mediated By Dna Polymerase Eta Proc.Natl.Acad.Sci.Usa V. 109 7269 2012.
Page generated: Thu Oct 10 11:00:42 2024
ISSN: ISSN 0027-8424 PubMed: 22529383 DOI: 10.1073/PNAS.1202681109 |
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