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Platinum in PDB 4dl7: Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4).

Enzymatic activity of Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4).

All present enzymatic activity of Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4).:
2.7.7.7;

Protein crystallography data

The structure of Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4)., PDB code: 4dl7 was solved by Y.Zhao, C.Biertumpfel, M.Gregory, Y.Hua, F.Hanaoka, W.Yang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 1.97
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 99.000, 99.000, 81.890, 90.00, 90.00, 120.00
R / Rfree (%) 19.2 / 21.4

Platinum Binding Sites:

The binding sites of Platinum atom in the Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4). (pdb code 4dl7). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4)., PDB code: 4dl7:

Platinum binding site 1 out of 1 in 4dl7

Go back to Platinum Binding Sites List in 4dl7
Platinum binding site 1 out of 1 in the Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4).


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Human Dna Polymerase Eta Fails to Extend Primer 2 Nucleotide After Cisplatin Crosslink (Pt-GG4). within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Pt101

b:21.4
occ:1.00
PT1 T:CPT101 0.0 21.4 1.0
N2 T:CPT101 2.0 16.5 1.0
N1 T:CPT101 2.1 17.0 1.0
N7 T:DG6 2.1 18.2 1.0
N7 T:DG7 2.1 20.1 1.0
C5 T:DG6 3.0 17.0 1.0
C8 T:DG7 3.0 16.4 1.0
C8 T:DG6 3.0 15.6 1.0
C5 T:DG7 3.1 18.0 1.0
O6 T:DG6 3.2 17.8 1.0
O T:HOH222 3.3 21.3 1.0
O6 T:DG7 3.4 16.7 1.0
C6 T:DG6 3.5 17.1 1.0
O T:HOH223 3.6 19.0 1.0
C6 T:DG7 3.6 18.6 1.0
C4 T:DG6 4.1 17.9 1.0
N9 T:DG6 4.1 13.9 1.0
N9 T:DG7 4.2 18.7 1.0
C4 T:DG7 4.2 19.0 1.0
O T:HOH209 4.6 18.6 1.0
CE1 A:PHE423 4.6 19.0 1.0
O T:HOH233 4.7 28.0 1.0
O T:HOH224 4.7 30.3 1.0
N1 T:DG6 4.8 20.7 1.0
N1 T:DG7 4.9 16.2 1.0

Reference:

Y.Zhao, C.Biertumpfel, M.T.Gregory, Y.J.Hua, F.Hanaoka, W.Yang. Structural Basis For Chemoresistance to Cisplatin Mediated By Dna Polymerase Eta Proc.Natl.Acad.Sci.Usa V. 109 7269 2012.
ISSN: ISSN 0027-8424
PubMed: 22529383
DOI: 10.1073/PNAS.1202681109
Page generated: Wed Dec 16 02:04:42 2020

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