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Platinum in PDB 4g4b: Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

Enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b was solved by S.W.M.Tanley, A.M.M.Schreurs, L.M.J.Kroon-Batenburg, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.74 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.822, 78.822, 38.019, 90.00, 90.00, 90.00
R / Rfree (%) 15.9 / 22.7

Other elements in 4g4b:

The structure of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage (pdb code 4g4b). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage, PDB code: 4g4b:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4g4b

Go back to Platinum Binding Sites List in 4g4b
Platinum binding site 1 out of 2 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:33.4
occ:0.50
 PT1 A:CPT201 0.0 33.4 0.5
N2 A:CPT201 2.1 34.0 1.0
N1 A:CPT201 2.1 31.5 1.0
NE2 A:HIS15 2.2 35.6 1.0
NH1 A:ARG14 2.3 50.2 1.0
CE1 A:HIS15 3.1 38.2 1.0
CD2 A:HIS15 3.3 34.3 1.0
CZ A:ARG14 3.5 48.2 1.0
NH2 A:ARG14 4.0 52.7 1.0
ND1 A:HIS15 4.3 37.9 1.0
CG A:HIS15 4.4 32.1 1.0
NE A:ARG14 4.4 46.3 1.0
OG1 A:THR89 4.6 29.2 1.0
CD A:ARG14 4.7 40.4 1.0
OD1 A:ASP87 4.7 34.7 1.0
OD2 A:ASP87 4.8 44.1 1.0
CB A:ALA11 4.9 22.9 1.0
CG A:ASP87 4.9 36.6 1.0

Platinum binding site 2 out of 2 in 4g4b

Go back to Platinum Binding Sites List in 4g4b
Platinum binding site 2 out of 2 in the Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Room Temperature X-Ray Diffraction Study of Cisplatin Binding to Hewl in Dmso Media with Nag After 7 Months of Crystal Storage within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt203

b:43.8
occ:0.80
 PT1 A:CPT203 0.0 43.8 0.8
N2 A:CPT203 2.2 24.4 1.0
ND1 A:HIS15 2.4 37.9 1.0
CL2 A:CPT203 2.4 59.3 1.0
CL1 A:CPT203 2.5 58.2 1.0
CG A:HIS15 3.3 32.1 1.0
CE1 A:HIS15 3.4 38.2 1.0
CB A:HIS15 3.5 28.7 1.0
CA A:HIS15 3.5 30.1 1.0
O A:HIS15 4.0 29.8 1.0
C A:HIS15 4.2 28.6 1.0
CD2 A:HIS15 4.4 34.3 1.0
NE2 A:HIS15 4.5 35.6 1.0
CG2 A:THR89 4.5 28.1 1.0
N A:HIS15 4.7 30.6 1.0
O A:ARG14 4.7 29.5 1.0
OG1 A:THR89 4.9 29.2 1.0
NZ A:LYS96 5.0 27.5 1.0

Reference:

S.W.Tanley, A.M.Schreurs, L.M.Kroon-Batenburg, J.R.Helliwell. Room-Temperature X-Ray Diffraction Studies of Cisplatin and Carboplatin Binding to HIS15 of Hewl After Prolonged Chemical Exposure. Acta Crystallogr.,Sect.F V. 68 1300 2012.
ISSN: ESSN 1744-3091
PubMed: 23143236
DOI: 10.1107/S1744309112042005
Page generated: Wed Dec 16 02:04:44 2020

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