Atomistry » Platinum » PDB 4dd7-4nsj » 4gcc
Atomistry »
  Platinum »
    PDB 4dd7-4nsj »
      4gcc »

Platinum in PDB 4gcc: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1, PDB code: 4gcc was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.47 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.863, 79.863, 37.802, 90.00, 90.00, 90.00
R / Rfree (%) 18.6 / 24.8

Other elements in 4gcc:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1 also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1 (pdb code 4gcc). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1, PDB code: 4gcc:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4gcc

Go back to Platinum Binding Sites List in 4gcc
Platinum binding site 1 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt205

b:53.3
occ:0.67
 PT1 A:CPT205 0.0 53.3 0.7
N2 A:CPT205 2.0 54.6 0.7
ND1 A:HIS15 2.3 39.0 1.0
CL1 A:CPT205 2.4 47.2 0.7
CL2 A:CPT205 2.5 49.5 0.7
CE1 A:HIS15 3.2 40.2 1.0
CG A:HIS15 3.3 35.2 1.0
CA A:HIS15 3.7 34.8 1.0
CB A:HIS15 3.7 33.7 1.0
O A:HIS15 4.3 34.9 1.0
NE2 A:HIS15 4.4 38.5 1.0
C A:HIS15 4.4 34.2 1.0
CD2 A:HIS15 4.5 36.2 1.0
CG2 A:THR89 4.5 31.2 1.0
O A:ARG14 4.6 34.6 1.0
N A:HIS15 4.7 36.4 1.0
OG1 A:THR89 5.0 32.6 1.0

Platinum binding site 2 out of 2 in 4gcc

Go back to Platinum Binding Sites List in 4gcc
Platinum binding site 2 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt206

b:56.5
occ:0.61
 PT1 A:CPT206 0.0 56.5 0.6
N2 A:CPT206 2.0 48.0 1.0
N1 A:CPT206 2.1 47.8 1.0
NE2 A:HIS15 2.3 38.5 1.0
NH1 A:ARG14 2.8 66.6 1.0
CE1 A:HIS15 3.1 40.2 1.0
CD2 A:HIS15 3.3 36.2 1.0
CZ A:ARG14 4.0 69.2 1.0
ND1 A:HIS15 4.3 39.0 1.0
CG A:HIS15 4.4 35.2 1.0
CD A:ARG14 4.5 57.9 1.0
NE A:ARG14 4.6 66.0 1.0
OG1 A:THR89 4.8 32.6 1.0
NH2 A:ARG14 4.8 74.5 1.0
CB A:ALA11 4.8 24.9 1.0
OD2 A:ASP87 4.9 46.1 1.0
O A:ALA11 4.9 27.6 1.0
CG1 A:ILE88 4.9 29.8 1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X
Page generated: Thu Oct 10 11:02:43 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy