Platinum in PDB 4gcd: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2, PDB code: 4gcd was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	35.74 / 2.80
*Space group*	P 4₃ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	79.863, 79.863, 37.802, 90.00, 90.00, 90.00
*R / R_free (%)*	17.5 / 24

Other elements in 4gcd:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 (pdb code 4gcd). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2, PDB code: 4gcd:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4gcd

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Platinum Binding Sites List in 4gcd

Platinum binding site 1 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Pt204 b:64.2 occ:0.66	PT1	A:CPT204	0.0	64.2	0.7
	N2	A:CPT204	2.0	58.9	0.7
	CL2	A:CPT204	2.4	45.6	0.7
	ND1	A:HIS15	2.6	49.2	1.0
	CE1	A:HIS15	3.3	50.1	1.0
	CG	A:HIS15	3.5	46.2	1.0
	CA	A:HIS15	3.7	43.0	1.0
	CB	A:HIS15	4.0	43.6	1.0
	NE2	A:HIS15	4.3	50.0	1.0
	O	A:HIS15	4.4	40.1	1.0
	C	A:HIS15	4.5	41.4	1.0
	CD2	A:HIS15	4.5	47.8	1.0
	O	A:ARG14	4.5	45.0	1.0
	CG2	A:THR89	4.6	33.0	1.0
	N	A:HIS15	4.7	44.8	1.0
	OD1	A:ASN93	5.0	36.2	1.0

Platinum binding site 2 out of 2 in 4gcd

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Platinum Binding Sites List in 4gcd

Platinum binding site 2 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 2 within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Pt205 b:64.5 occ:0.55	PT1	A:CPT205	0.0	64.5	0.6
	N2	A:CPT205	2.0	60.3	0.6
	N1	A:CPT205	2.0	58.2	0.6
	NE2	A:HIS15	2.6	50.0	1.0
	NH1	A:ARG14	3.3	63.9	1.0
	CD2	A:HIS15	3.3	47.8	1.0
	CE1	A:HIS15	3.6	50.1	1.0
	NH2	A:ARG14	4.1	64.8	1.0
	CZ	A:ARG14	4.2	65.5	1.0
	OD2	A:ASP87	4.2	41.0	1.0
	CG	A:HIS15	4.5	46.2	1.0
	ND1	A:HIS15	4.7	49.2	1.0
	OG1	A:THR89	4.8	33.4	1.0
	CB	A:ALA11	4.9	37.2	1.0
	CG1	A:ILE88	4.9	29.1	1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X

Page generated: Wed Dec 16 02:04:45 2020

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