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Platinum in PDB 4gce: Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

Enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3

All present enzymatic activity of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce was solved by J.R.Helliwell, S.W.M.Tanley, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.47 / 2.90
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.863, 79.863, 37.802, 90.00, 90.00, 90.00
R / Rfree (%) 17.4 / 23.4

Other elements in 4gce:

The structure of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 (pdb code 4gce). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3, PDB code: 4gce:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4gce

Go back to Platinum Binding Sites List in 4gce
Platinum binding site 1 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:61.5
occ:0.60
 PT1 A:CPT202 0.0 61.5 0.6
N1 A:CPT202 2.0 52.6 0.6
ND1 A:HIS15 2.3 42.1 1.0
CL2 A:CPT202 2.4 51.3 0.6
CE1 A:HIS15 3.1 43.5 1.0
CG A:HIS15 3.4 39.2 1.0
CA A:HIS15 3.7 38.9 1.0
CB A:HIS15 3.8 37.6 1.0
O A:HIS15 4.2 38.5 1.0
NE2 A:HIS15 4.3 42.1 1.0
C A:HIS15 4.3 38.5 1.0
CG2 A:THR89 4.4 30.2 1.0
CD2 A:HIS15 4.5 40.3 1.0
O A:ARG14 4.5 40.3 1.0
N A:HIS15 4.8 39.5 1.0
OD1 A:ASN93 4.9 32.9 1.0

Platinum binding site 2 out of 2 in 4gce

Go back to Platinum Binding Sites List in 4gce
Platinum binding site 2 out of 2 in the Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Room Temperature X-Ray Diffraction Study of A 6-Fold Molar Excess of A Cisplatin/Carboplatin Mixture Binding to Hewl, Dataset 3 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt203

b:74.6
occ:0.78
 PT1 A:CPT203 0.0 74.6 0.8
N1 A:CPT203 2.0 67.0 1.0
N2 A:CPT203 2.1 71.3 1.0
NE2 A:HIS15 2.5 42.1 1.0
NH2 A:ARG14 3.1 51.0 1.0
CD2 A:HIS15 3.3 40.3 1.0
CE1 A:HIS15 3.5 43.5 1.0
NE A:ARG14 3.8 49.2 1.0
CZ A:ARG14 3.9 51.4 1.0
OD2 A:ASP87 4.1 37.9 1.0
CG A:HIS15 4.5 39.2 1.0
ND1 A:HIS15 4.5 42.1 1.0
OG1 A:THR89 4.7 31.2 1.0
O A:ALA11 4.9 30.1 1.0

Reference:

J.R.Helliwell, S.W.Tanley. The Crystal Structure Analysis of the Relative Binding of Cisplatin and Carboplatin in A Mixture with Histidine in A Protein Studied at 100 and 300 K with Repeated X-Ray Irradiation. Acta Crystallogr.,Sect.D V. 69 121 2013.
ISSN: ISSN 0907-4449
PubMed: 23275170
DOI: 10.1107/S090744491204423X
Page generated: Thu Oct 10 11:02:48 2024

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