Platinum in PDB 4hga: Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx

The structure of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx, PDB code: 4hga was solved by C.P.Liu, C.Y.Xiong, M.Z.Wang, Z.L.Yu, N.Yang, P.Chen, Z.G.Zhang, G.H.Li, R.M.Xu, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.93 / 2.80
Space group	P 61 2 2
Cell size a, b, c (Å), α, β, γ (°)	72.103, 72.103, 323.550, 90.00, 90.00, 120.00
R / Rfree (%)	20.8 / 27.1

The structure of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx also contains other interesting chemical elements:

Chlorine

(Cl)

9 atoms

The binding sites of Platinum atom in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx (pdb code 4hga). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 4 binding sites of Platinum where determined in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx, PDB code: 4hga:
Jump to Platinum binding site number: 1; 2; 3; 4;

Platinum binding site 1 out of 4 in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt401 b:0.7 occ:0.50 PT A:PC4401 0.0 0.7 0.5 CL2 A:PC4401 2.4 74.3 0.5 CL3 A:PC4401 2.4 77.7 0.5 CL1 A:PC4401 2.4 0.9 0.5 CL4 A:PC4401 2.4 0.2 0.5 NH2 A:ARG323 4.0 86.8 1.0 CB A:ARG260 4.2 93.9 1.0 N A:ARG260 4.3 85.3 1.0 NH1 A:ARG323 4.4 86.2 1.0 CZ A:ARG323 4.5 84.1 1.0 C A:ARG260 4.7 91.5 1.0 CA A:ARG260 4.7 91.5 1.0 O A:ARG260 4.8 94.6 1.0 CG A:ARG260 5.0 97.6 1.0

Platinum binding site 2 out of 4 in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt402 b:0.7 occ:0.90 PT A:PC4402 0.0 0.7 0.9 CL4 A:PC4402 2.4 0.9 0.9 CL3 A:PC4402 2.4 0.5 0.9 CL2 A:PC4402 2.4 96.5 0.9 SD A:MET312 3.0 0.4 1.0 CG A:MET312 3.5 78.9 1.0 CB A:MET312 3.6 78.5 1.0 CE A:MET312 3.6 87.2 1.0 CE2 A:TYR264 4.0 0.1 1.0 CD2 A:TYR264 4.3 0.1 1.0 CA A:MET312 4.9 76.5 1.0 O A:GLN308 4.9 88.4 1.0

Platinum binding site 3 out of 4 in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt403 b:90.5 occ:0.20 SD A:MET369 3.4 0.6 1.0 CB A:MET369 3.4 62.0 1.0 CG A:MET369 3.6 67.7 1.0 NE A:ARG365 3.7 69.5 1.0 CG A:ARG365 4.1 69.4 1.0 CZ A:ARG365 4.2 70.0 1.0 O A:ARG365 4.3 63.9 1.0 CD A:ARG365 4.3 68.9 1.0 NH2 A:ARG365 4.3 66.8 1.0 CE A:MET369 4.4 59.5 1.0 CA A:MET369 4.8 63.0 1.0 C A:ARG365 4.9 69.4 1.0

Platinum binding site 4 out of 4 in the Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt201 b:0.1 occ:0.60 PT B:PC4201 0.0 0.1 0.6 CL4 B:PC4201 2.4 0.6 0.6 CL1 B:PC4201 2.4 0.1 0.6 SD B:MET120 3.1 0.6 1.0 CG B:MET120 3.3 84.2 1.0 CE B:MET120 3.4 76.5 1.0 CG A:GLN383 3.7 99.4 1.0 CB B:MET120 3.8 79.7 1.0 OG C:SER47 3.9 94.4 1.0 NE2 A:GLN383 3.9 94.8 1.0 CD A:GLN383 3.9 94.8 1.0 CB C:SER47 4.3 87.1 1.0 OE1 A:GLN383 4.7 92.6 1.0 CD1 C:LEU49 4.7 86.8 1.0 CD B:PRO121 4.9 80.5 1.0 CB A:GLN383 4.9 0.2 1.0 CA B:MET120 4.9 72.4 1.0

C.P.Liu, C.Y.Xiong, M.Z.Wang, Z.L.Yu, N.Yang, P.Chen, Z.G.Zhang, G.H.Li, R.M.Xu. Structure of the Variant Histone H3.3-H4 Heterodimer in Complex with Its Chaperone Daxx. Nat.Struct.Mol.Biol. V. 19 1287 2012.
ISSN: ISSN 1545-9993
PubMed: 23142979
DOI: 10.1038/NSMB.2439