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Platinum in PDB 4lt2: Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package

Enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package

All present enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package:
3.2.1.17;

Protein crystallography data

The structure of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package, PDB code: 4lt2 was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.15 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.294, 77.294, 36.628, 90.00, 90.00, 90.00
R / Rfree (%) 20.8 / 26.5

Platinum Binding Sites:

The binding sites of Platinum atom in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package (pdb code 4lt2). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package, PDB code: 4lt2:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4lt2

Go back to Platinum Binding Sites List in 4lt2
Platinum binding site 1 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:77.1
occ:0.33
PT1 A:QPT201 0.0 77.1 0.3
O1 A:QPT201 2.0 47.8 1.0
NH1 A:ARG14 2.7 40.2 1.0
O A:HOH361 2.8 42.8 1.0
NE2 A:HIS15 2.9 25.2 1.0
O A:DMS206 3.1 60.6 1.0
CE1 A:HIS15 3.6 23.8 1.0
OD1 A:ASP87 3.7 29.5 1.0
CZ A:ARG14 4.0 38.9 1.0
CD2 A:HIS15 4.0 25.7 1.0
N A:ILE88 4.2 18.9 1.0
S A:DMS206 4.3 76.0 1.0
CG1 A:ILE88 4.4 17.5 1.0
OG1 A:THR89 4.4 23.4 1.0
CG A:ASP87 4.5 26.8 1.0
CA A:ASP87 4.5 20.4 1.0
NH2 A:ARG14 4.6 43.0 1.0
CB A:ALA11 4.8 17.2 1.0
ND1 A:HIS15 4.8 24.4 1.0
C A:ASP87 4.8 20.2 1.0
NE A:ARG14 4.9 39.2 1.0
CB A:ASP87 5.0 23.4 1.0
CD A:ARG14 5.0 33.8 1.0

Platinum binding site 2 out of 2 in 4lt2

Go back to Platinum Binding Sites List in 4lt2
Platinum binding site 2 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Eval Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt208

b:49.6
occ:0.27
PT1 A:QPT208 0.0 49.6 0.3
O1 A:QPT208 2.0 45.7 1.0
N2 A:QPT208 2.0 47.9 1.0
ND1 A:HIS15 2.9 24.4 1.0
C1 A:QPT208 3.0 43.2 1.0
O4 A:QPT208 3.5 40.0 1.0
CG A:HIS15 3.7 23.2 1.0
CB A:HIS15 3.8 24.4 1.0
CA A:HIS15 3.8 24.0 1.0
CE1 A:HIS15 3.9 23.8 1.0
O A:HIS15 4.2 26.3 1.0
OD1 A:ASN93 4.2 35.5 1.0
CG2 A:THR89 4.4 19.0 1.0
C A:HIS15 4.5 24.3 1.0
CD2 A:HIS15 4.9 25.7 1.0
NE2 A:HIS15 5.0 25.2 1.0

Reference:

S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, A.M.M.Schreurs, J.R.Helliwell. Carboplatin Binding to A Model Protein in Non-Nacl Conditions to Eliminate Partial Conversion to Cisplatin, and the Use of Different Criteria to Choose the Resolution Limit To Be Published.
Page generated: Wed Dec 16 02:04:48 2020

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