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Platinum in PDB 4lt3: Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package

Enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package

All present enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package:
3.2.1.17;

Protein crystallography data

The structure of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package, PDB code: 4lt3 was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.28 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.120, 77.120, 36.560, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 25.8

Platinum Binding Sites:

The binding sites of Platinum atom in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package (pdb code 4lt3). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package, PDB code: 4lt3:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4lt3

Go back to Platinum Binding Sites List in 4lt3
Platinum binding site 1 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt207

b:51.0
occ:0.23
PT1 A:QPT207 0.0 51.0 0.2
O1 A:QPT207 2.0 53.9 1.0
ND1 A:HIS15 2.7 28.4 1.0
C1 A:QPT207 3.0 49.4 1.0
CE1 A:HIS15 3.6 27.3 1.0
CG A:HIS15 3.7 28.0 1.0
CA A:HIS15 3.8 28.0 1.0
CB A:HIS15 3.9 29.3 1.0
O A:HIS15 4.0 30.9 1.0
OD1 A:ASN93 4.2 40.8 1.0
C A:HIS15 4.4 28.4 1.0
CG2 A:THR89 4.5 24.8 1.0
NE2 A:HIS15 4.8 31.1 1.0
CD2 A:HIS15 4.8 31.1 1.0
ND2 A:ASN93 4.8 38.5 1.0
CG A:ASN93 4.9 33.6 1.0
O A:ARG14 4.9 23.5 1.0
N A:HIS15 5.0 28.0 1.0

Platinum binding site 2 out of 2 in 4lt3

Go back to Platinum Binding Sites List in 4lt3
Platinum binding site 2 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt208

b:86.6
occ:0.38
PT1 A:QPT208 0.0 86.6 0.4
O1 A:QPT208 2.0 69.4 1.0
O2 A:QPT208 2.0 61.7 1.0
NE2 A:HIS15 2.8 31.1 1.0
C1 A:QPT208 3.0 66.3 1.0
C2 A:QPT208 3.0 63.0 1.0
NH1 A:ARG14 3.5 49.8 1.0
OD1 A:ASP87 3.6 32.7 1.0
CE1 A:HIS15 3.7 27.3 1.0
CD2 A:HIS15 3.8 31.1 1.0
N A:ILE88 3.9 25.4 1.0
OG1 A:THR89 4.1 30.5 1.0
CG1 A:ILE88 4.1 23.5 1.0
O4 A:QPT208 4.2 64.5 1.0
CG A:ASP87 4.3 31.9 1.0
CA A:ASP87 4.4 25.4 1.0
O A:HOH336 4.5 46.2 1.0
C A:ASP87 4.6 27.0 1.0
CB A:ASP87 4.7 27.4 1.0
N A:THR89 4.7 22.4 1.0
CZ A:ARG14 4.8 52.1 1.0
ND1 A:HIS15 4.9 28.4 1.0
CA A:ILE88 4.9 24.9 1.0
CB A:ALA11 4.9 24.4 1.0
CG A:HIS15 5.0 28.0 1.0

Reference:

S.W.Tanley, K.Diederichs, L.M.Kroon-Batenburg, C.Levy, A.M.Schreurs, J.R.Helliwell. Carboplatin Binding to Histidine. Acta Crystallogr.,Sect.F V. 70 1135 2014.
ISSN: ISSN 1744-3091
PubMed: 25195881
DOI: 10.1107/S2053230X14016161
Page generated: Thu Oct 10 11:04:37 2024

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