Atomistry » Platinum » PDB 3wua-4nsi » 4lt3
Atomistry »
  Platinum »
    PDB 3wua-4nsi »
      4lt3 »

Platinum in PDB 4lt3: Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package

Enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package

All present enzymatic activity of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package:
3.2.1.17;

Protein crystallography data

The structure of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package, PDB code: 4lt3 was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.28 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.120, 77.120, 36.560, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 25.8

Platinum Binding Sites:

The binding sites of Platinum atom in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package (pdb code 4lt3). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package, PDB code: 4lt3:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4lt3

Go back to Platinum Binding Sites List in 4lt3
Platinum binding site 1 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt207

b:51.0
occ:0.23
PT1 A:QPT207 0.0 51.0 0.2
O1 A:QPT207 2.0 53.9 1.0
ND1 A:HIS15 2.7 28.4 1.0
C1 A:QPT207 3.0 49.4 1.0
CE1 A:HIS15 3.6 27.3 1.0
CG A:HIS15 3.7 28.0 1.0
CA A:HIS15 3.8 28.0 1.0
CB A:HIS15 3.9 29.3 1.0
O A:HIS15 4.0 30.9 1.0
OD1 A:ASN93 4.2 40.8 1.0
C A:HIS15 4.4 28.4 1.0
CG2 A:THR89 4.5 24.8 1.0
NE2 A:HIS15 4.8 31.1 1.0
CD2 A:HIS15 4.8 31.1 1.0
ND2 A:ASN93 4.8 38.5 1.0
CG A:ASN93 4.9 33.6 1.0
O A:ARG14 4.9 23.5 1.0
N A:HIS15 5.0 28.0 1.0

Platinum binding site 2 out of 2 in 4lt3

Go back to Platinum Binding Sites List in 4lt3
Platinum binding site 2 out of 2 in the Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Hewl Co-Crystallized with Carboplatin in Non-Nacl Conditions: Crystal 2 Processed Using the Xds Software Package within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt208

b:86.6
occ:0.38
PT1 A:QPT208 0.0 86.6 0.4
O1 A:QPT208 2.0 69.4 1.0
O2 A:QPT208 2.0 61.7 1.0
NE2 A:HIS15 2.8 31.1 1.0
C1 A:QPT208 3.0 66.3 1.0
C2 A:QPT208 3.0 63.0 1.0
NH1 A:ARG14 3.5 49.8 1.0
OD1 A:ASP87 3.6 32.7 1.0
CE1 A:HIS15 3.7 27.3 1.0
CD2 A:HIS15 3.8 31.1 1.0
N A:ILE88 3.9 25.4 1.0
OG1 A:THR89 4.1 30.5 1.0
CG1 A:ILE88 4.1 23.5 1.0
O4 A:QPT208 4.2 64.5 1.0
CG A:ASP87 4.3 31.9 1.0
CA A:ASP87 4.4 25.4 1.0
O A:HOH336 4.5 46.2 1.0
C A:ASP87 4.6 27.0 1.0
CB A:ASP87 4.7 27.4 1.0
N A:THR89 4.7 22.4 1.0
CZ A:ARG14 4.8 52.1 1.0
ND1 A:HIS15 4.9 28.4 1.0
CA A:ILE88 4.9 24.9 1.0
CB A:ALA11 4.9 24.4 1.0
CG A:HIS15 5.0 28.0 1.0

Reference:

S.W.Tanley, K.Diederichs, L.M.Kroon-Batenburg, C.Levy, A.M.Schreurs, J.R.Helliwell. Carboplatin Binding to Histidine. Acta Crystallogr.,Sect.F V. 70 1135 2014.
ISSN: ISSN 1744-3091
PubMed: 25195881
DOI: 10.1107/S2053230X14016161
Page generated: Wed Dec 16 02:04:48 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy