Platinum in PDB 4n0z: Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

Enzymatic activity of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

All present enzymatic activity of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1):
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1), PDB code: 4n0z was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	24.20 / 1.70
*Space group*	P 3₂ 2 1
*Cell size a, b, c (Å), α, β, γ (°)*	48.400, 48.400, 82.612, 90.00, 90.00, 120.00
*R / R_free (%)*	15.5 / 17.2

Other elements in 4n0z:

The structure of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) (pdb code 4n0z). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1), PDB code: 4n0z:

Platinum binding site 1 out of 1 in 4n0z

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Platinum Binding Sites List in 4n0z

Platinum binding site 1 out of 1 in the Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1)

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Cisplatin Bound to A Plasmodium Falciparum Glutaredoxin 1 (PFGRX1) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Pt203 b:43.8 occ:0.26	PT1	A:CPT203	0.0	43.8	0.3
	N1	A:CPT203	2.0	32.7	0.3
	CL1	A:CPT203	2.3	31.6	0.3
	ND1	A:HIS49	2.6	34.4	1.0
	O	A:HOH406	2.9	31.0	1.0
	CG	A:HIS49	3.5	26.2	1.0
	O	A:MET48	3.6	21.7	0.5
	O	A:MET48	3.6	21.1	0.5
	CB	A:HIS49	3.6	21.9	1.0
	CA	A:HIS49	3.6	18.6	1.0
	CE1	A:HIS49	3.6	35.9	1.0
	O	A:HOH381	4.0	38.3	1.0
	C	A:MET48	4.5	19.8	0.5
	C	A:MET48	4.5	19.9	0.5
	N	A:VAL50	4.5	17.3	1.0
	N	A:HIS49	4.5	18.8	1.0
	C	A:HIS49	4.6	18.3	1.0
	CD2	A:HIS49	4.7	26.8	1.0
	NE2	A:HIS49	4.7	26.4	1.0
	O	A:HOH314	4.8	27.5	1.0

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.

Page generated: Mon Aug 18 23:41:28 2025

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