Atomistry » Platinum » PDB 4dd7-4nsj » 4n11
Atomistry »
  Platinum »
    PDB 4dd7-4nsj »
      4n11 »

Platinum in PDB 4n11: Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

Enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin:
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11 was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.46 / 1.97
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 48.478, 48.478, 82.391, 90.00, 90.00, 120.00
R / Rfree (%) 15.7 / 20.8

Other elements in 4n11:

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin (pdb code 4n11). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 3 binding sites of Platinum where determined in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11:
Jump to Platinum binding site number: 1; 2; 3;

Platinum binding site 1 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 1 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:36.2
occ:0.40
 PT1 A:CPT204 0.0 36.2 0.4
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Platinum binding site 2 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 2 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:39.1
occ:0.30
 PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 36.2 0.4
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Platinum binding site 3 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 3 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:39.1
occ:0.30
 PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 36.2 0.4
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.
Page generated: Thu Oct 10 11:05:34 2024

Last articles

Zn in 7WU0
Zn in 7WTZ
Zn in 7WTX
Zn in 7WTW
Zn in 7WT5
Zn in 7WTU
Zn in 7WTV
Zn in 7WTT
Zn in 7WT4
Zn in 7WT3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy