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Platinum in PDB 4n11: Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

Enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin

All present enzymatic activity of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin:
1.20.4.1;

Protein crystallography data

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11 was solved by M.Yogavel, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.46 / 1.97
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 48.478, 48.478, 82.391, 90.00, 90.00, 120.00
R / Rfree (%) 15.7 / 20.8

Other elements in 4n11:

The structure of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin (pdb code 4n11). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 3 binding sites of Platinum where determined in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin, PDB code: 4n11:
Jump to Platinum binding site number: 1; 2; 3;

Platinum binding site 1 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 1 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:36.2
occ:0.40
 PT1 A:CPT204 0.0 36.2 0.4
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Platinum binding site 2 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 2 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:39.1
occ:0.30
 PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 36.2 0.4
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Platinum binding site 3 out of 3 in 4n11

Go back to Platinum Binding Sites List in 4n11
Platinum binding site 3 out of 3 in the Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of Plasmodium Falciparum Reduced Glutaredoxin 1 (PFGRX1) Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt204

b:39.1
occ:0.30
 PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 39.1 0.3
PT1 A:CPT204 0.0 36.2 0.4
N2 A:CPT204 1.9 33.1 0.3
N2 A:CPT204 2.0 31.6 0.4
N1 A:CPT204 2.0 39.4 0.3
N1 A:CPT204 2.1 38.6 0.4
CL1 A:CPT204 2.1 31.1 0.3
CL1 A:CPT204 2.3 29.5 0.4
N1 A:CPT204 2.3 35.3 0.3
NZ A:LYS26 2.4 50.6 0.5
SG A:CYS29 2.6 34.5 1.0
CL1 A:CPT204 2.9 38.3 0.3
CB A:CYS29 3.3 26.4 1.0
CE A:LYS26 3.8 48.0 0.5
CA A:CYS29 4.0 25.2 1.0
CD A:LYS26 4.7 40.0 0.5
O A:HOH377 4.7 26.6 0.6
CG A:LYS26 4.7 38.5 0.5
C A:CYS29 4.7 22.7 1.0
CD A:PRO30 4.8 25.6 1.0
O A:VAL75 4.8 23.3 1.0
O A:HOH316 4.9 32.6 0.5
CG A:LYS26 4.9 38.5 0.5
CD A:LYS26 4.9 40.0 0.5

Reference:

M.Yogavel, T.Tripathi, S.Rahlfs, K.Becker, A.Sharma. Interaction of Cisplatin with Plasmodium Falciparum Glutaredoxin 1 To Be Published.
Page generated: Thu Oct 10 11:05:34 2024

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