Atomistry » Platinum » PDB 3wua-4nsi » 4nsg
Atomistry »
  Platinum »
    PDB 3wua-4nsi »
      4nsg »

Platinum in PDB 4nsg: Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A

Enzymatic activity of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A

All present enzymatic activity of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A:
3.2.1.17;

Protein crystallography data

The structure of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A, PDB code: 4nsg was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, C.Levy, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.42 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.377, 78.377, 37.213, 90.00, 90.00, 90.00
R / Rfree (%) 21.9 / 27.1

Other elements in 4nsg:

The structure of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A also contains other interesting chemical elements:

Bromine (Br) 9 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A (pdb code 4nsg). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A, PDB code: 4nsg:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4nsg

Go back to Platinum Binding Sites List in 4nsg
Platinum binding site 1 out of 2 in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt220

b:18.4
occ:0.94
ND1 A:HIS15 2.2 16.1 1.0
BR A:BR204 2.5 22.1 0.9
BR A:BR203 2.5 18.5 0.9
CE1 A:HIS15 3.1 16.0 1.0
CG A:HIS15 3.1 16.0 1.0
CB A:HIS15 3.4 16.0 1.0
CA A:HIS15 3.5 16.0 1.0
O A:HOH303 4.1 22.4 1.0
NE2 A:HIS15 4.2 15.9 1.0
CD2 A:HIS15 4.2 15.9 1.0
O A:HIS15 4.2 16.4 1.0
C A:HIS15 4.3 16.2 1.0
N A:HIS15 4.6 15.8 1.0
CG2 A:THR89 4.7 12.5 1.0
O A:ARG14 4.8 15.8 1.0
OG1 A:THR89 4.8 12.6 1.0

Platinum binding site 2 out of 2 in 4nsg

Go back to Platinum Binding Sites List in 4nsg
Platinum binding site 2 out of 2 in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt221

b:43.3
occ:0.28
NH1 A:ARG14 2.1 17.8 1.0
BR A:BR201 2.3 11.3 0.4
NE2 A:HIS15 2.7 15.9 1.0
CZ A:ARG14 3.3 17.5 1.0
CE1 A:HIS15 3.5 16.0 1.0
CD2 A:HIS15 3.8 15.9 1.0
O A:HOH369 3.8 28.7 1.0
NH2 A:ARG14 3.9 17.9 1.0
NE A:ARG14 4.2 17.1 1.0
OD2 A:ASP87 4.3 13.8 1.0
OD1 A:ASP87 4.3 13.5 1.0
CD A:ARG14 4.4 16.7 1.0
CG A:ASP87 4.4 13.4 1.0
ND1 A:HIS15 4.7 16.1 1.0
OG1 A:THR89 4.8 12.6 1.0
CG A:HIS15 4.8 16.0 1.0
N A:ILE88 5.0 12.7 1.0
CG1 A:ILE88 5.0 12.7 1.0
CB A:ALA11 5.0 12.0 1.0

Reference:

S.W.Tanley, K.Diederichs, L.M.Kroon-Batenburg, C.Levy, A.M.Schreurs, J.R.Helliwell. Carboplatin Binding to Histidine. Acta Crystallogr F Struct V. 70 1135 2014BIOL Commun.
PubMed: 25195881
DOI: 10.1107/S2053230X14016161
Page generated: Wed Dec 16 02:04:51 2020

Last articles

Tb in 6TVY
Si in 6Y7O
Rh in 6WRM
Rh in 6WRL
Ni in 6Y8Z
Ni in 6Y8Y
Na in 6ZXZ
Na in 7ACG
Na in 6YLS
Na in 6Y8Z
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy