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Platinum in PDB 4nsg: Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A

Enzymatic activity of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A

All present enzymatic activity of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A:
3.2.1.17;

Protein crystallography data

The structure of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A, PDB code: 4nsg was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, C.Levy, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.42 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.377, 78.377, 37.213, 90.00, 90.00, 90.00
R / Rfree (%) 21.9 / 27.1

Other elements in 4nsg:

The structure of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A also contains other interesting chemical elements:

Bromine (Br) 9 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A (pdb code 4nsg). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A, PDB code: 4nsg:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4nsg

Go back to Platinum Binding Sites List in 4nsg
Platinum binding site 1 out of 2 in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt220

b:18.4
occ:0.94
ND1 A:HIS15 2.2 16.1 1.0
BR A:BR204 2.5 22.1 0.9
BR A:BR203 2.5 18.5 0.9
CE1 A:HIS15 3.1 16.0 1.0
CG A:HIS15 3.1 16.0 1.0
CB A:HIS15 3.4 16.0 1.0
CA A:HIS15 3.5 16.0 1.0
O A:HOH303 4.1 22.4 1.0
NE2 A:HIS15 4.2 15.9 1.0
CD2 A:HIS15 4.2 15.9 1.0
O A:HIS15 4.2 16.4 1.0
C A:HIS15 4.3 16.2 1.0
N A:HIS15 4.6 15.8 1.0
CG2 A:THR89 4.7 12.5 1.0
O A:ARG14 4.8 15.8 1.0
OG1 A:THR89 4.8 12.6 1.0

Platinum binding site 2 out of 2 in 4nsg

Go back to Platinum Binding Sites List in 4nsg
Platinum binding site 2 out of 2 in the Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Carboplatin Binding to Hewl in Nabr Crystallisation Conditions Studied at An X-Ray Wavelength of 1.5418A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt221

b:43.3
occ:0.28
NH1 A:ARG14 2.1 17.8 1.0
BR A:BR201 2.3 11.3 0.4
NE2 A:HIS15 2.7 15.9 1.0
CZ A:ARG14 3.3 17.5 1.0
CE1 A:HIS15 3.5 16.0 1.0
CD2 A:HIS15 3.8 15.9 1.0
O A:HOH369 3.8 28.7 1.0
NH2 A:ARG14 3.9 17.9 1.0
NE A:ARG14 4.2 17.1 1.0
OD2 A:ASP87 4.3 13.8 1.0
OD1 A:ASP87 4.3 13.5 1.0
CD A:ARG14 4.4 16.7 1.0
CG A:ASP87 4.4 13.4 1.0
ND1 A:HIS15 4.7 16.1 1.0
OG1 A:THR89 4.8 12.6 1.0
CG A:HIS15 4.8 16.0 1.0
N A:ILE88 5.0 12.7 1.0
CG1 A:ILE88 5.0 12.7 1.0
CB A:ALA11 5.0 12.0 1.0

Reference:

S.W.Tanley, K.Diederichs, L.M.Kroon-Batenburg, C.Levy, A.M.Schreurs, J.R.Helliwell. Carboplatin Binding to Histidine. Acta Crystallogr F Struct V. 70 1135 2014BIOL Commun.
PubMed: 25195881
DOI: 10.1107/S2053230X14016161
Page generated: Wed Dec 16 02:04:51 2020

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