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Platinum in PDB 4nsh: Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6

Enzymatic activity of Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6

All present enzymatic activity of Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6:
3.2.1.17;

Protein crystallography data

The structure of Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6, PDB code: 4nsh was solved by S.W.M.Tanley, K.Diederichs, L.M.J.Kroon-Batenburg, C.Levy, A.M.M.Schreurs, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.71 / 2.10
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.085, 77.085, 37.143, 90.00, 90.00, 90.00
R / Rfree (%) 19.6 / 26.2

Platinum Binding Sites:

The binding sites of Platinum atom in the Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6 (pdb code 4nsh). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6, PDB code: 4nsh:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4nsh

Go back to Platinum Binding Sites List in 4nsh
Platinum binding site 1 out of 2 in the Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt207

b:54.2
occ:0.40
PT1 A:QPT207 0.0 54.2 0.4
O1 A:QPT207 2.0 55.8 1.0
N1 A:QPT207 2.0 47.2 1.0
NH1 A:ARG14 2.4 41.2 1.0
NE2 A:HIS15 2.8 28.2 1.0
C1 A:QPT207 2.9 49.7 1.0
CD2 A:HIS15 3.5 27.4 1.0
CZ A:ARG14 3.7 40.2 1.0
CE1 A:HIS15 3.8 28.9 1.0
OD1 A:ASP87 4.3 27.9 1.0
CD A:ARG14 4.4 35.3 1.0
NE A:ARG14 4.4 38.0 1.0
NH2 A:ARG14 4.5 41.5 1.0
CB A:ALA11 4.6 18.8 1.0
CG1 A:ILE88 4.7 21.1 1.0
CG A:HIS15 4.8 27.3 1.0
OG1 A:THR89 4.8 21.2 1.0
ND1 A:HIS15 4.9 28.3 1.0
N A:ILE88 5.0 21.4 1.0

Platinum binding site 2 out of 2 in 4nsh

Go back to Platinum Binding Sites List in 4nsh
Platinum binding site 2 out of 2 in the Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Carboplatin Binding to Hewl in 0.2M NH4SO4, 0.1M Naac in 25% Peg 4000 at pH 4.6 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt209

b:41.7
occ:0.49
PT1 A:QPT209 0.0 41.7 0.5
O2 A:QPT209 2.0 42.1 1.0
O1 A:QPT209 2.0 40.5 1.0
N2 A:QPT209 2.0 43.1 1.0
ND1 A:HIS15 2.2 28.3 1.0
C2 A:QPT209 3.0 42.3 1.0
CE1 A:HIS15 3.1 28.9 1.0
CG A:HIS15 3.2 27.3 1.0
CB A:HIS15 3.5 26.5 1.0
CA A:HIS15 3.7 26.8 1.0
O A:HIS15 4.1 25.8 1.0
NE2 A:HIS15 4.3 28.2 1.0
CD2 A:HIS15 4.3 27.4 1.0
C A:HIS15 4.4 26.7 1.0
O A:HOH365 4.4 39.2 1.0
CG2 A:THR89 4.7 21.3 1.0
OG1 A:THR89 4.7 21.2 1.0
N A:HIS15 4.8 26.7 1.0
O A:ARG14 4.9 27.4 1.0

Reference:

S.W.Tanley, K.Diederichs, L.M.Kroon-Batenburg, C.Levy, A.M.Schreurs, J.R.Helliwell. Carboplatin Binding to Histidine. Acta Crystallogr F Struct V. 70 1135 2014BIOL Commun.
PubMed: 25195881
DOI: 10.1107/S2053230X14016161
Page generated: Wed Dec 16 02:04:51 2020

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