Platinum in PDB 4owc: PTI6 Binding to Hewl

All present enzymatic activity of PTI6 Binding to Hewl:
3.2.1.17;

The structure of PTI6 Binding to Hewl, PDB code: 4owc was solved by S.W.M.Tanley, V.L.Starkey, L.Lamplough, S.Kaenket, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.82 / 1.62
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	78.689, 78.689, 36.939, 90.00, 90.00, 90.00
R / Rfree (%)	17.4 / 19.3

The structure of PTI6 Binding to Hewl also contains other interesting chemical elements:

Iodine	(I)	8 atoms
Chlorine	(Cl)	4 atoms
Sodium	(Na)	1 atom

The binding sites of Platinum atom in the PTI6 Binding to Hewl (pdb code 4owc). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the PTI6 Binding to Hewl, PDB code: 4owc:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the PTI6 Binding to Hewl


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of PTI6 Binding to Hewl within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt209 b:13.7 occ:0.78 ND1 A:HIS15 2.1 16.3 1.0 I A:IOD201 2.6 14.5 0.8 I A:IOD203 2.6 15.8 0.8 I A:IOD202 2.6 13.1 0.8 CE1 A:HIS15 3.1 16.3 1.0 CG A:HIS15 3.1 16.2 1.0 CB A:HIS15 3.4 15.7 1.0 CA A:HIS15 3.5 15.6 1.0 O A:HIS15 4.0 15.4 1.0 C A:HIS15 4.2 16.2 1.0 NE2 A:HIS15 4.2 15.5 1.0 CD2 A:HIS15 4.3 14.5 1.0 N A:HIS15 4.6 14.4 1.0 O A:ARG14 4.7 16.4 1.0 NZ A:LYS96 4.8 15.1 1.0 CG2 A:THR89 4.8 13.9 1.0 O A:HOH381 4.9 16.9 1.0

Platinum binding site 2 out of 2 in the PTI6 Binding to Hewl


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of PTI6 Binding to Hewl within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt210 b:16.2 occ:0.47 I A:IOD206 2.6 20.4 0.5 I A:IOD207 2.6 14.1 0.5 I A:IOD204 2.7 16.2 0.5 I A:IOD205 2.7 17.3 0.5 CD A:ARG14 4.9 17.3 1.0

S.W.Tanley, L.V.Starkey, L.Lamplough, S.Kaenket, J.R.Helliwell. The Binding of Platinum Hexahalides (Cl, Br and I) to Hen Egg-White Lysozyme and the Chemical Transformation of the PTI6 Octahedral Complex to A PTI3 Moiety Bound to HIS15. Acta Crystallogr.,Sect.F V. 70 1132 2014.
ISSN: ESSN 2053-230X
PubMed: 25195880
DOI: 10.1107/S2053230X14014009