Platinum in PDB 4owe: PTCL6 Binding to Hewl

All present enzymatic activity of PTCL6 Binding to Hewl:
3.2.1.17;

The structure of PTCL6 Binding to Hewl, PDB code: 4owe was solved by S.W.M.Tanley, V.L.Starkey, L.Lamplough, S.Kaenket, J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.68 / 1.41
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	78.748, 78.748, 37.160, 90.00, 90.00, 90.00
R / Rfree (%)	18.5 / 22.3

The structure of PTCL6 Binding to Hewl also contains other interesting chemical elements:

Chlorine	(Cl)	17 atoms
Sodium	(Na)	1 atom

The binding sites of Platinum atom in the PTCL6 Binding to Hewl (pdb code 4owe). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the PTCL6 Binding to Hewl, PDB code: 4owe:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the PTCL6 Binding to Hewl


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of PTCL6 Binding to Hewl within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt218 b:17.3 occ:0.36 CL A:CL202 2.2 21.6 0.4 CL A:CL201 2.3 24.2 0.4 CL A:CL206 2.3 20.8 0.4 CL A:CL204 2.3 24.6 0.4 CL A:CL203 2.4 19.5 0.4 CL A:CL205 2.5 11.5 0.4 ND2 A:ASN65 4.4 21.7 1.0 O A:HOH346 4.8 18.6 1.0 O A:HOH393 4.8 28.9 1.0 CB A:PRO79 4.8 18.3 1.0

Platinum binding site 2 out of 2 in the PTCL6 Binding to Hewl


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of PTCL6 Binding to Hewl within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt219 b:19.5 occ:0.22 CL A:CL209 2.4 21.5 0.2 CL A:CL208 2.4 30.4 0.2 CL A:CL207 2.4 29.8 0.2 NE A:ARG14 4.4 33.4 1.0 CA A:ALA11 4.9 19.3 1.0 NH2 A:ARG14 5.0 31.8 1.0

S.W.Tanley, L.V.Starkey, L.Lamplough, S.Kaenket, J.R.Helliwell. The Binding of Platinum Hexahalides (Cl, Br and I) to Hen Egg-White Lysozyme and the Chemical Transformation of the PTI6 Octahedral Complex to A PTI3 Moiety Bound to HIS15. Acta Crystallogr.,Sect.F V. 70 1132 2014.
ISSN: ESSN 2053-230X
PubMed: 25195880
DOI: 10.1107/S2053230X14014009