Atomistry » Platinum » PDB 4nsj-5bna » 4qgz
Atomistry »
  Platinum »
    PDB 4nsj-5bna »
      4qgz »

Platinum in PDB 4qgz: X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)

Enzymatic activity of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)

All present enzymatic activity of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II):
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II), PDB code: 4qgz was solved by I.Russo Krauss, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.10 / 2.51
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.920, 77.920, 36.921, 90.00, 90.00, 90.00
R / Rfree (%) 17.9 / 25.9

Platinum Binding Sites:

The binding sites of Platinum atom in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) (pdb code 4qgz). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II), PDB code: 4qgz:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4qgz

Go back to Platinum Binding Sites List in 4qgz
Platinum binding site 1 out of 2 in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:62.5
occ:0.80
PT A:I83201 0.0 62.5 0.8
N18 A:I83201 2.0 44.9 0.8
N21 A:I83201 2.0 52.9 0.8
O A:HOH355 2.0 55.0 0.8
NE2 A:HIS15 2.4 70.3 1.0
CE1 A:HIS15 3.1 65.3 1.0
CD2 A:HIS15 3.2 60.3 1.0
NH2 A:ARG14 3.8 82.9 1.0
ND1 A:HIS15 4.0 63.8 1.0
CG A:HIS15 4.1 60.5 1.0
NE A:ARG14 4.3 75.3 1.0
OG1 A:THR89 4.4 53.7 1.0
CZ A:ARG14 4.5 82.0 1.0
O A:HOH327 4.7 19.2 0.5

Platinum binding site 2 out of 2 in 4qgz

Go back to Platinum Binding Sites List in 4qgz
Platinum binding site 2 out of 2 in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:84.9
occ:0.35
PT A:I83202 0.0 84.9 0.3
O A:HOH356 1.9 76.7 0.3
N21 A:I83202 2.0 76.9 0.3
N18 A:I83202 2.0 76.0 0.3
OD2 A:ASP101 2.1 81.5 1.0
CG A:ASP101 3.4 76.0 1.0
OD1 A:ASP101 4.1 80.9 1.0
O A:ASP101 4.2 63.2 1.0
CB A:ASP101 4.4 67.6 1.0

Reference:

L.Messori, T.Marzo, E.Michelucci, I.Russo Krauss, C.Navarro-Ranninger, A.G.Quiroga, A.Merlino. Interactions Between Anticancer Trans-Platinum Compounds and Proteins: Crystal Structures and Esi-Ms Spectra of Two Protein Adducts of Trans-(Dimethylamino)(Methylamino)Dichloridoplatinum(II). Inorg.Chem. V. 53 7806 2014.
ISSN: ISSN 0020-1669
PubMed: 25025479
DOI: 10.1021/IC5012583
Page generated: Wed Dec 16 02:04:59 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy