Platinum in PDB 4qgz: X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)

All present enzymatic activity of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II):
3.2.1.17;

The structure of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II), PDB code: 4qgz was solved by I.Russo Krauss, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	55.10 / 2.51
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	77.920, 77.920, 36.921, 90.00, 90.00, 90.00
R / Rfree (%)	17.9 / 25.9

The binding sites of Platinum atom in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) (pdb code 4qgz). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II), PDB code: 4qgz:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt201 b:62.5 occ:0.80 PT A:I83201 0.0 62.5 0.8 N18 A:I83201 2.0 44.9 0.8 N21 A:I83201 2.0 52.9 0.8 O A:HOH355 2.0 55.0 0.8 NE2 A:HIS15 2.4 70.3 1.0 CE1 A:HIS15 3.1 65.3 1.0 CD2 A:HIS15 3.2 60.3 1.0 NH2 A:ARG14 3.8 82.9 1.0 ND1 A:HIS15 4.0 63.8 1.0 CG A:HIS15 4.1 60.5 1.0 NE A:ARG14 4.3 75.3 1.0 OG1 A:THR89 4.4 53.7 1.0 CZ A:ARG14 4.5 82.0 1.0 O A:HOH327 4.7 19.2 0.5

Platinum binding site 2 out of 2 in the X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II)


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of X-Ray Structure of the Adduct Formed Between Hen Egg White Lysozyme and Trans-Dimethylamine Methylamine Dichlorido Platinum(II) within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt202 b:84.9 occ:0.35 PT A:I83202 0.0 84.9 0.3 O A:HOH356 1.9 76.7 0.3 N21 A:I83202 2.0 76.9 0.3 N18 A:I83202 2.0 76.0 0.3 OD2 A:ASP101 2.1 81.5 1.0 CG A:ASP101 3.4 76.0 1.0 OD1 A:ASP101 4.1 80.9 1.0 O A:ASP101 4.2 63.2 1.0 CB A:ASP101 4.4 67.6 1.0

L.Messori, T.Marzo, E.Michelucci, I.Russo Krauss, C.Navarro-Ranninger, A.G.Quiroga, A.Merlino. Interactions Between Anticancer Trans-Platinum Compounds and Proteins: Crystal Structures and Esi-Ms Spectra of Two Protein Adducts of Trans-(Dimethylamino)(Methylamino)Dichloridoplatinum(II). Inorg.Chem. V. 53 7806 2014.
ISSN: ISSN 0020-1669
PubMed: 25025479
DOI: 10.1021/IC5012583