Platinum in PDB 4s1y: X-Ray Structure of Human Serum Albumin Complexed with Cisplatin

The structure of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin, PDB code: 4s1y was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	57.46 / 3.16
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	57.789, 86.474, 59.141, 90.00, 103.70, 90.00
R / Rfree (%)	22.3 / 32.9

The structure of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Platinum atom in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin (pdb code 4s1y). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 5 binding sites of Platinum where determined in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin, PDB code: 4s1y:
Jump to Platinum binding site number: 1; 2; 3; 4; 5;

Platinum binding site 1 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt601 b:62.1 occ:0.80 PT1 A:CPT601 0.0 62.1 0.8 N2 A:CPT601 2.0 60.9 0.8 N1 A:CPT601 2.0 62.0 0.8 ND1 A:HIS105 2.2 79.8 1.0 CL1 A:CPT601 2.3 57.6 0.8 CG A:HIS105 2.9 86.3 1.0 CB A:HIS105 2.9 74.8 1.0 CA A:HIS105 3.3 65.6 1.0 CE1 A:HIS105 3.4 90.7 1.0 O A:HIS105 3.5 62.0 1.0 C A:HIS105 3.9 58.7 1.0 CD2 A:HIS105 4.1 90.8 1.0 NE2 A:HIS105 4.3 93.4 1.0 N A:HIS105 4.5 61.3 1.0 O A:GLN104 4.7 59.9 1.0

Platinum binding site 2 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt602 b:58.0 occ:0.80 PT1 A:CPT602 0.0 58.0 0.8 N2 A:CPT602 2.0 56.6 0.8 N1 A:CPT602 2.0 53.3 0.8 SD A:MET329 2.2 50.0 1.0 CL1 A:CPT602 2.3 57.4 0.8 CG A:MET329 3.1 44.2 1.0 CB A:MET329 3.2 41.8 1.0 CE A:MET329 3.9 52.4 1.0 CA A:MET329 4.3 38.4 1.0 OE2 A:GLU333 4.5 36.2 1.0 C A:MET329 4.8 35.7 1.0 O A:MET329 4.9 33.8 1.0 CG A:GLU333 4.9 34.7 1.0 CZ A:PHE309 5.0 49.7 1.0

Platinum binding site 3 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt603 b:68.0 occ:0.40 SD A:MET548 2.2 82.0 1.0 CE A:MET548 3.4 73.4 1.0 CG A:MET548 3.6 83.3 1.0 CB A:MET548 3.8 82.9 1.0 CA A:LYS545 4.0 66.5 1.0 N A:LYS545 4.3 66.2 1.0 CB A:LYS545 4.6 60.1 1.0 C A:LEU544 4.7 69.7 1.0 O A:LEU544 4.7 71.7 1.0 O A:LYS545 5.0 68.2 1.0 C A:LYS545 5.0 67.9 1.0

Platinum binding site 4 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt604 b:58.9 occ:0.45 SD A:MET298 2.2 72.0 1.0 CG A:MET298 3.5 75.9 1.0 CE A:MET298 3.7 67.0 1.0 CB A:MET298 4.1 77.7 1.0 O A:PRO299 4.7 79.5 1.0 O A:MET298 4.7 86.0 1.0

Platinum binding site 5 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt605 b:63.9 occ:0.30 NE2 A:HIS288 2.3 51.8 1.0 CE1 A:HIS288 3.2 48.8 1.0 CD2 A:HIS288 3.2 46.6 1.0 OE2 A:GLU188 3.3 69.0 1.0 ND1 A:HIS288 4.3 47.0 1.0 CD A:GLU188 4.4 70.0 1.0 CG A:HIS288 4.4 44.3 1.0 CG A:GLU292 4.6 69.5 1.0 OE1 A:GLU188 4.8 68.8 1.0 CE2 A:PHE156 4.8 53.1 1.0

G.Ferraro, L.Massai, L.Messori, A.Merlino. Cisplatin Binding to Human Serum Albumin: A Structural Study. Chem.Commun.(Camb.) 2015.
ISSN: ESSN 1364-548X
PubMed: 25873085
DOI: 10.1039/C5CC01751C