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Platinum in PDB 4s1y: X-Ray Structure of Human Serum Albumin Complexed with Cisplatin

Protein crystallography data

The structure of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin, PDB code: 4s1y was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 57.46 / 3.16
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 57.789, 86.474, 59.141, 90.00, 103.70, 90.00
R / Rfree (%) 22.3 / 32.9

Other elements in 4s1y:

The structure of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin (pdb code 4s1y). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 5 binding sites of Platinum where determined in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin, PDB code: 4s1y:
Jump to Platinum binding site number: 1; 2; 3; 4; 5;

Platinum binding site 1 out of 5 in 4s1y

Go back to Platinum Binding Sites List in 4s1y
Platinum binding site 1 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt601

b:62.1
occ:0.80
PT1 A:CPT601 0.0 62.1 0.8
N2 A:CPT601 2.0 60.9 0.8
N1 A:CPT601 2.0 62.0 0.8
ND1 A:HIS105 2.2 79.8 1.0
CL1 A:CPT601 2.3 57.6 0.8
CG A:HIS105 2.9 86.3 1.0
CB A:HIS105 2.9 74.8 1.0
CA A:HIS105 3.3 65.6 1.0
CE1 A:HIS105 3.4 90.7 1.0
O A:HIS105 3.5 62.0 1.0
C A:HIS105 3.9 58.7 1.0
CD2 A:HIS105 4.1 90.8 1.0
NE2 A:HIS105 4.3 93.4 1.0
N A:HIS105 4.5 61.3 1.0
O A:GLN104 4.7 59.9 1.0

Platinum binding site 2 out of 5 in 4s1y

Go back to Platinum Binding Sites List in 4s1y
Platinum binding site 2 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt602

b:58.0
occ:0.80
PT1 A:CPT602 0.0 58.0 0.8
N2 A:CPT602 2.0 56.6 0.8
N1 A:CPT602 2.0 53.3 0.8
SD A:MET329 2.2 50.0 1.0
CL1 A:CPT602 2.3 57.4 0.8
CG A:MET329 3.1 44.2 1.0
CB A:MET329 3.2 41.8 1.0
CE A:MET329 3.9 52.4 1.0
CA A:MET329 4.3 38.4 1.0
OE2 A:GLU333 4.5 36.2 1.0
C A:MET329 4.8 35.7 1.0
O A:MET329 4.9 33.8 1.0
CG A:GLU333 4.9 34.7 1.0
CZ A:PHE309 5.0 49.7 1.0

Platinum binding site 3 out of 5 in 4s1y

Go back to Platinum Binding Sites List in 4s1y
Platinum binding site 3 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt603

b:68.0
occ:0.40
SD A:MET548 2.2 82.0 1.0
CE A:MET548 3.4 73.4 1.0
CG A:MET548 3.6 83.3 1.0
CB A:MET548 3.8 82.9 1.0
CA A:LYS545 4.0 66.5 1.0
N A:LYS545 4.3 66.2 1.0
CB A:LYS545 4.6 60.1 1.0
C A:LEU544 4.7 69.7 1.0
O A:LEU544 4.7 71.7 1.0
O A:LYS545 5.0 68.2 1.0
C A:LYS545 5.0 67.9 1.0

Platinum binding site 4 out of 5 in 4s1y

Go back to Platinum Binding Sites List in 4s1y
Platinum binding site 4 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt604

b:58.9
occ:0.45
SD A:MET298 2.2 72.0 1.0
CG A:MET298 3.5 75.9 1.0
CE A:MET298 3.7 67.0 1.0
CB A:MET298 4.1 77.7 1.0
O A:PRO299 4.7 79.5 1.0
O A:MET298 4.7 86.0 1.0

Platinum binding site 5 out of 5 in 4s1y

Go back to Platinum Binding Sites List in 4s1y
Platinum binding site 5 out of 5 in the X-Ray Structure of Human Serum Albumin Complexed with Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of X-Ray Structure of Human Serum Albumin Complexed with Cisplatin within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt605

b:63.9
occ:0.30
NE2 A:HIS288 2.3 51.8 1.0
CE1 A:HIS288 3.2 48.8 1.0
CD2 A:HIS288 3.2 46.6 1.0
OE2 A:GLU188 3.3 69.0 1.0
ND1 A:HIS288 4.3 47.0 1.0
CD A:GLU188 4.4 70.0 1.0
CG A:HIS288 4.4 44.3 1.0
CG A:GLU292 4.6 69.5 1.0
OE1 A:GLU188 4.8 68.8 1.0
CE2 A:PHE156 4.8 53.1 1.0

Reference:

G.Ferraro, L.Massai, L.Messori, A.Merlino. Cisplatin Binding to Human Serum Albumin: A Structural Study. Chem.Commun.(Camb.) 2015.
ISSN: ESSN 1364-548X
PubMed: 25873085
DOI: 10.1039/C5CC01751C
Page generated: Wed Dec 16 02:05:03 2020

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