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Platinum in PDB 4yen: Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement

Enzymatic activity of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement

All present enzymatic activity of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement:
3.2.1.17;

Protein crystallography data

The structure of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement, PDB code: 4yen was solved by I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.00
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.113, 79.113, 37.985, 90.00, 90.00, 90.00
R / Rfree (%) 14.6 / 17.9

Other elements in 4yen:

The structure of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement (pdb code 4yen). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement, PDB code: 4yen:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 4yen

Go back to Platinum Binding Sites List in 4yen
Platinum binding site 1 out of 2 in the Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt200

b:38.0
occ:0.40
CL A:CL205 2.2 29.0 0.4
NH1 A:ARG14 2.3 41.3 1.0
CL A:CL206 2.3 37.7 0.4
NE2 A:HIS15 2.3 31.4 1.0
CE1 A:HIS15 3.1 32.4 1.0
CZ A:ARG14 3.2 40.3 1.0
CD2 A:HIS15 3.4 30.0 1.0
NE A:ARG14 3.5 37.7 1.0
NH2 A:ARG14 4.3 42.2 1.0
ND1 A:HIS15 4.3 31.8 1.0
OD1 A:ASP87 4.4 36.8 1.0
CG A:HIS15 4.5 29.2 1.0
OG1 A:THR89 4.7 28.8 1.0
OD2 A:ASP87 4.7 41.1 1.0
CG A:ASP87 4.8 36.8 1.0
CG1 A:ILE88 4.9 27.1 1.0
CB A:ALA11 4.9 24.7 1.0
CD A:ARG14 4.9 37.1 1.0

Platinum binding site 2 out of 2 in 4yen

Go back to Platinum Binding Sites List in 4yen
Platinum binding site 2 out of 2 in the Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Room Temperature X-Ray Diffraction Studies of Cisplatin Binding to Hewl in Dmso Media After 14 Months of Crystal Storage - New Refinement within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:40.6
occ:0.80
CL A:CL204 2.2 44.8 0.8
ND1 A:HIS15 2.3 31.8 1.0
CL A:CL202 2.3 35.7 0.8
CL A:CL203 2.5 51.8 0.8
CG A:HIS15 3.2 29.2 1.0
CE1 A:HIS15 3.2 32.4 1.0
CB A:HIS15 3.5 27.6 1.0
CA A:HIS15 3.6 28.2 1.0
O A:HIS15 4.1 28.1 1.0
C A:HIS15 4.3 27.9 1.0
NE2 A:HIS15 4.3 31.4 1.0
CD2 A:HIS15 4.4 30.0 1.0
O A:HOH370 4.5 51.1 1.0
N A:HIS15 4.7 27.6 1.0
CG2 A:THR89 4.7 28.3 1.0
O A:ARG14 4.8 29.4 1.0
OG1 A:THR89 4.8 28.8 1.0

Reference:

I.G.Shabalin, Z.Dauter, M.Jaskolski, W.Minor, A.Wlodawer. Crystallography and Chemistry Should Always Go Together: A Cautionary Tale of Protein Complexes with Cisplatin and Carboplatin To Be Published.
Page generated: Wed Dec 16 02:05:05 2020

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