Platinum in PDB 4z3m: X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B)

Enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B)

All present enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B):
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B), PDB code: 4z3m was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	55.34 / 2.15
*Space group*	P 4₃ 2₁ 2
*Cell size a, b, c (Å), α, β, γ (°)*	78.261, 78.261, 36.878, 90.00, 90.00, 90.00
*R / R_free (%)*	16 / 23.3

Platinum Binding Sites:

The binding sites of Platinum atom in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B) (pdb code 4z3m). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B), PDB code: 4z3m:

Platinum binding site 1 out of 1 in 4z3m

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Platinum Binding Sites List in 4z3m

Platinum binding site 1 out of 1 in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B)

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Complex with S,O Bidentate Ligands (9B) within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Pt201 b:30.8 occ:0.60	PT1	A:4KV201	0.0	30.8	0.6
	O1	A:4KV201	2.0	30.7	0.6
	S3	A:4KV201	2.2	32.6	0.6
	S1	A:4KV201	2.2	33.1	0.6
	ND1	A:HIS15	2.4	37.1	1.0
	C3	A:4KV201	3.0	30.4	0.6
	O2	A:4KV201	3.1	33.5	0.6
	C13	A:4KV201	3.2	32.1	0.6
	C1	A:4KV201	3.2	34.5	0.6
	CE1	A:HIS15	3.3	38.0	1.0
	C12	A:4KV201	3.3	28.4	0.6
	CG	A:HIS15	3.3	32.5	1.0
	C2	A:4KV201	3.4	32.6	0.6
	CA	A:HIS15	3.5	28.0	1.0
	CB	A:HIS15	3.6	30.1	1.0
	O	A:HIS15	4.1	23.1	1.0
	C	A:HIS15	4.2	24.7	1.0
	C4	A:4KV201	4.3	31.1	0.6
	O	A:ARG14	4.3	28.7	0.5
	O	A:ARG14	4.3	28.9	0.5
	NE2	A:HIS15	4.4	38.0	1.0
	CD2	A:HIS15	4.4	34.9	1.0
	N	A:HIS15	4.5	30.1	1.0
	C9	A:4KV201	4.7	30.9	0.6
	C	A:ARG14	4.7	27.8	0.5
	C	A:ARG14	4.8	28.0	0.5
	S2	A:4KV201	4.9	37.7	0.6

Reference:

C.Mugge, T.Marzo, L.Massai, J.Hildebrandt, G.Ferraro, P.Rivera-Fuentes, N.Metzler-Nolte, A.Merlino, L.Messori, W.Weigand. Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding. Inorg.Chem. V. 54 8560 2015.
ISSN: ISSN 0020-1669
PubMed: 26280387
DOI: 10.1021/ACS.INORGCHEM.5B01238

Page generated: Wed Dec 16 02:05:07 2020

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