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Platinum in PDB 4z41: X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))

Enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))

All present enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)):
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)), PDB code: 4z41 was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.41 / 1.89
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.364, 78.364, 37.069, 90.00, 90.00, 90.00
R / Rfree (%) 16.3 / 21.9

Platinum Binding Sites:

The binding sites of Platinum atom in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)) (pdb code 4z41). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)), PDB code: 4z41:

Platinum binding site 1 out of 1 in 4z41

Go back to Platinum Binding Sites List in 4z41
Platinum binding site 1 out of 1 in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:22.1
occ:0.60
PT1 A:4KV201 0.0 22.1 0.6
O1 A:4KV201 2.0 21.5 0.6
S3 A:4KV201 2.2 23.7 0.6
S1 A:4KV201 2.2 30.2 0.6
ND1 A:HIS15 2.3 29.5 1.0
C3 A:4KV201 3.0 23.1 0.6
O2 A:4KV201 3.1 24.9 0.6
C13 A:4KV201 3.2 22.6 0.6
C12 A:4KV201 3.2 21.1 0.6
C1 A:4KV201 3.3 31.2 0.6
CE1 A:HIS15 3.3 32.5 1.0
CG A:HIS15 3.3 25.9 1.0
C2 A:4KV201 3.5 27.1 0.6
CA A:HIS15 3.5 22.2 1.0
CB A:HIS15 3.6 23.9 1.0
C4 A:4KV201 4.2 23.4 0.6
O A:ARG14 4.2 23.1 1.0
C A:HIS15 4.3 20.3 1.0
O A:HIS15 4.3 20.5 1.0
NE2 A:HIS15 4.4 32.0 1.0
CD2 A:HIS15 4.4 28.6 1.0
N A:HIS15 4.4 21.1 1.0
C9 A:4KV201 4.7 21.5 0.6
C A:ARG14 4.7 21.2 1.0
S2 A:4KV201 4.9 36.7 0.6

Reference:

C.Mugge, T.Marzo, L.Massai, J.Hildebrandt, G.Ferraro, P.Rivera-Fuentes, N.Metzler-Nolte, A.Merlino, L.Messori, W.Weigand. Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding. Inorg.Chem. V. 54 8560 2015.
ISSN: ISSN 0020-1669
PubMed: 26280387
DOI: 10.1021/ACS.INORGCHEM.5B01238
Page generated: Wed Dec 16 02:05:07 2020

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