Atomistry » Platinum » PDB 4omb-5djl » 4z41
Atomistry »
  Platinum »
    PDB 4omb-5djl »
      4z41 »

Platinum in PDB 4z41: X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))

Enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))

All present enzymatic activity of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)):
3.2.1.17;

Protein crystallography data

The structure of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)), PDB code: 4z41 was solved by A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.41 / 1.89
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.364, 78.364, 37.069, 90.00, 90.00, 90.00
R / Rfree (%) 16.3 / 21.9

Platinum Binding Sites:

The binding sites of Platinum atom in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)) (pdb code 4z41). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)), PDB code: 4z41:

Platinum binding site 1 out of 1 in 4z41

Go back to Platinum Binding Sites List in 4z41
Platinum binding site 1 out of 1 in the X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II))


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of X-Ray Structure of the Adduct Formed in the Reaction Between Lysozyme and A Platinum(II) Compound with A S,O Bidentate Ligand (9A=Chloro- (1-(3'-Hydroxy)-3-(Methylthio)-3-Thioxo-Prop-1-En-1-Olate-O,S)- (Dimethylsulfoxide-S)-Platinum(II)) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:22.1
occ:0.60
 PT1 A:4KV201 0.0 22.1 0.6
O1 A:4KV201 2.0 21.5 0.6
S3 A:4KV201 2.2 23.7 0.6
S1 A:4KV201 2.2 30.2 0.6
ND1 A:HIS15 2.3 29.5 1.0
C3 A:4KV201 3.0 23.1 0.6
O2 A:4KV201 3.1 24.9 0.6
C13 A:4KV201 3.2 22.6 0.6
C12 A:4KV201 3.2 21.1 0.6
C1 A:4KV201 3.3 31.2 0.6
CE1 A:HIS15 3.3 32.5 1.0
CG A:HIS15 3.3 25.9 1.0
C2 A:4KV201 3.5 27.1 0.6
CA A:HIS15 3.5 22.2 1.0
CB A:HIS15 3.6 23.9 1.0
C4 A:4KV201 4.2 23.4 0.6
O A:ARG14 4.2 23.1 1.0
C A:HIS15 4.3 20.3 1.0
O A:HIS15 4.3 20.5 1.0
NE2 A:HIS15 4.4 32.0 1.0
CD2 A:HIS15 4.4 28.6 1.0
N A:HIS15 4.4 21.1 1.0
C9 A:4KV201 4.7 21.5 0.6
C A:ARG14 4.7 21.2 1.0
S2 A:4KV201 4.9 36.7 0.6

Reference:

C.Mugge, T.Marzo, L.Massai, J.Hildebrandt, G.Ferraro, P.Rivera-Fuentes, N.Metzler-Nolte, A.Merlino, L.Messori, W.Weigand. Platinum(II) Complexes with O,S Bidentate Ligands: Biophysical Characterization, Antiproliferative Activity, and Crystallographic Evidence of Protein Binding. Inorg.Chem. V. 54 8560 2015.
ISSN: ISSN 0020-1669
PubMed: 26280387
DOI: 10.1021/ACS.INORGCHEM.5B01238
Page generated: Wed Dec 16 02:05:07 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy