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Platinum in PDB 4z46: X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin
Enzymatic activity of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin
All present enzymatic activity of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin:
3.2.1.17;
3.2.1.17;
Protein crystallography data
The structure of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin, PDB code: 4z46
was solved by
A.Merlino,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 54.67 / 1.85 |
| Space group | P 43 21 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 77.318, 77.318, 37.325, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.5 / 21.8 |
Other elements in 4z46:
The structure of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
| Sodium | (Na) | 2 atoms |
Platinum Binding Sites:
The binding sites of Platinum atom in the X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin
(pdb code 4z46). This binding sites where shown within
5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin, PDB code: 4z46:
Jump to Platinum binding site number: 1; 2;
In total 2 binding sites of Platinum where determined in the X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin, PDB code: 4z46:
Jump to Platinum binding site number: 1; 2;
Platinum binding site 1 out of 2 in 4z46
Go back to
Platinum Binding Sites List in 4z46
Platinum binding site 1 out
of 2 in the X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Platinum with other atoms in the Pt binding
site number 1 of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin within 5.0Å range:
|
Platinum binding site 2 out of 2 in 4z46
Go back to
Platinum Binding Sites List in 4z46
Platinum binding site 2 out
of 2 in the X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Platinum with other atoms in the Pt binding
site number 2 of X-Ray Structure of the Bis-Platinum Lysozyme Adduct Formed in the Reaction Between the Protein and the Two Drugs Cisplatin and Oxaliplatin within 5.0Å range:
|
Reference:
D.Marasco,
L.Messori,
T.Marzo,
A.Merlino.
Oxaliplatin Vs. Cisplatin: Competition Experiments on Their Binding to Lysozyme. Dalton Trans 2015.
ISSN: ESSN 1477-9234
PubMed: 25974859
DOI: 10.1039/C5DT01279A
Page generated: Thu Oct 10 11:31:50 2024
ISSN: ESSN 1477-9234
PubMed: 25974859
DOI: 10.1039/C5DT01279A
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