Platinum in PDB 5hhi: Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G

Enzymatic activity of Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G

All present enzymatic activity of Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G:
2.7.7.7;

Protein crystallography data

The structure of Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G, PDB code: 5hhi was solved by S.Lee, M.-C.Koag, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	18.26 / 2.52
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	54.372, 80.119, 54.674, 90.00, 108.94, 90.00
*R / R_free (%)*	22.2 / 27.9

Other elements in 5hhi:

The structure of Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G also contains other interesting chemical elements:

Sodium

(Na)

2 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G (pdb code 5hhi). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G, PDB code: 5hhi:

Platinum binding site 1 out of 1 in 5hhi

Go back to

Platinum Binding Sites List in 5hhi

Platinum binding site 1 out of 1 in the Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G

Mono view

Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Structure of Human Dna Polymerase Beta Host-Guest Complexed with Cbz- Platinated N7-G within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
P:Pt101 b:68.6 occ:1.00	PT1	P:61C101	0.0	68.6	1.0
	N7	P:DG4	2.0	69.4	1.0
	N2	P:61C101	2.0	64.3	1.0
	N3	P:61C101	2.0	70.4	1.0
	N4	P:61C101	2.1	68.6	1.0
	C14	P:61C101	2.8	55.8	1.0
	C8	P:DG4	2.9	71.9	1.0
	C5	P:DG4	3.2	58.2	1.0
	O6	P:DG4	3.7	49.0	1.0
	C6	P:DG4	3.8	54.6	1.0
	C13	P:61C101	4.1	57.5	1.0
	N9	P:DG4	4.1	68.4	1.0
	C4	P:DG4	4.3	62.9	1.0
	C7	P:DT3	4.4	48.7	1.0
	N1	P:61C101	4.5	63.5	1.0
	OP2	P:DT3	4.6	64.0	1.0
	C5	P:DT3	4.7	62.5	1.0
	C6	P:DT3	4.7	63.3	1.0
	C12	P:61C101	4.7	60.4	1.0
	C11	P:61C101	4.7	60.8	1.0

Reference:

Y.Cheun, M.C.Koag, Y.W.Naguib, H.Ouzon-Shubeita, Z.Cui, D.Pakotiprapha, S.Lee. Synthesis, Structure, and Biological Evaluation of A Platinum-Carbazole Conjugate. Chem Biol Drug Des V. 91 116 2018.
ISSN: ESSN 1747-0285
PubMed: 28649747
DOI: 10.1111/CBDD.13062

Page generated: Thu Oct 10 11:35:20 2024

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