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Platinum in PDB 5hq1: Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.

Enzymatic activity of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.

All present enzymatic activity of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.:
3.2.1.17;

Protein crystallography data

The structure of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted., PDB code: 5hq1 was solved by J.R.Helliwell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 32.09 / 1.00
Space group P 1
Cell size a, b, c (Å), α, β, γ (°) 26.777, 31.382, 33.865, 88.90, 72.31, 68.46
R / Rfree (%) 17.2 / 19.7

Other elements in 5hq1:

The structure of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. (pdb code 5hq1). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 4 binding sites of Platinum where determined in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted., PDB code: 5hq1:
Jump to Platinum binding site number: 1; 2; 3; 4;

Platinum binding site 1 out of 4 in 5hq1

Go back to Platinum Binding Sites List in 5hq1
Platinum binding site 1 out of 4 in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt205

b:13.3
occ:0.14
 CE1 A:HIS15 2.2 30.8 1.0
PT A:PT206 2.5 7.1 0.2
NE2 A:HIS15 2.5 38.2 1.0
PT A:PT207 3.0 0.3 0.4
OG1 A:THR89 3.3 15.3 1.0
ND1 A:HIS15 3.4 32.0 1.0
O A:HOH301 3.8 19.2 1.0
CD2 A:HIS15 3.8 33.5 1.0
CG A:HIS15 4.3 31.1 1.0
CB A:THR89 4.5 9.9 1.0
CG2 A:THR89 4.5 11.2 1.0
PT A:PT208 4.9 11.8 0.3

Platinum binding site 2 out of 4 in 5hq1

Go back to Platinum Binding Sites List in 5hq1
Platinum binding site 2 out of 4 in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt206

b:7.1
occ:0.16
 PT A:PT207 1.8 0.3 0.4
PT A:PT205 2.5 13.3 0.1
NE2 A:HIS15 2.7 38.2 1.0
CE1 A:HIS15 3.3 30.8 1.0
CD2 A:HIS15 3.5 33.5 1.0
NE A:ARG14 3.8 15.2 1.0
CB A:ARG14 4.1 16.7 1.0
CD A:ARG14 4.1 14.4 1.0
ND1 A:HIS15 4.2 32.0 1.0
CG A:HIS15 4.3 31.1 1.0
CG A:ARG14 4.8 16.7 1.0
CZ A:ARG14 4.9 18.5 1.0
OG1 A:THR89 4.9 15.3 1.0

Platinum binding site 3 out of 4 in 5hq1

Go back to Platinum Binding Sites List in 5hq1
Platinum binding site 3 out of 4 in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt207

b:0.3
occ:0.44
 PT A:PT206 1.8 7.1 0.2
NE2 A:HIS15 2.7 38.2 1.0
PT A:PT205 3.0 13.3 0.1
CD2 A:HIS15 3.4 33.5 1.0
CE1 A:HIS15 3.7 30.8 1.0
NE A:ARG14 4.0 15.2 1.0
OG1 A:THR89 4.3 15.3 1.0
NH2 A:ARG14 4.5 19.9 1.0
CG A:HIS15 4.6 31.1 1.0
ND1 A:HIS15 4.7 32.0 1.0
CZ A:ARG14 4.8 18.5 1.0
O A:HOH301 4.8 19.2 1.0
CD A:ARG14 4.9 14.4 1.0
O A:ALA11 4.9 10.6 1.0

Platinum binding site 4 out of 4 in 5hq1

Go back to Platinum Binding Sites List in 5hq1
Platinum binding site 4 out of 4 in the Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted.


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of Comment on S. W. M. Tanley and J. R. Helliwell Structural Dynamics of Cisplatin Binding to Histidine in A Protein Struct. Dyn. 1, 034701 (2014) Regarding the Refinement of 4MWK, 4MWM, 4MWN and 4OXE and the Method We Have Adopted. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt208

b:11.8
occ:0.29
 ND1 A:HIS15 2.1 32.0 1.0
CL A:CL209 2.2 11.2 0.3
CL A:CL212 2.3 13.5 0.3
CG A:HIS15 3.0 31.1 1.0
CE1 A:HIS15 3.1 30.8 1.0
CB A:HIS15 3.4 18.2 1.0
CA A:HIS15 3.6 19.1 1.0
O A:HIS15 4.1 20.9 1.0
CD2 A:HIS15 4.2 33.5 1.0
OD1 A:ASN93 4.2 30.3 1.0
NE2 A:HIS15 4.2 38.2 1.0
C A:HIS15 4.3 16.0 1.0
CG2 A:THR89 4.5 11.2 1.0
NZ A:LYS96 4.7 18.2 1.0
N A:HIS15 4.8 14.7 1.0
O A:ARG14 4.9 17.6 1.0
PT A:PT205 4.9 13.3 0.1

Reference:

S.W.Tanley, J.R.Helliwell. Comment on "Structural Dynamics of Cisplatin Binding to Histidine in A Protein" [Struct. Dyn. 1, 034701 (2014)]. Struct Dyn V. 3 37101 2016.
ISSN: ESSN 2329-7778
PubMed: 27226979
DOI: 10.1063/1.4948613
Page generated: Thu Oct 10 11:35:54 2024

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