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Platinum in PDB 5ihg: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ihg was solved by G.Ferraro, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.85 / 1.75
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.575, 77.575, 37.253, 90.00, 90.00, 90.00
R / Rfree (%) 16.2 / 20.3

Other elements in 5ihg:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand also contains other interesting chemical elements:

Chlorine (Cl) 3 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand (pdb code 5ihg). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ihg:

Platinum binding site 1 out of 1 in 5ihg

Go back to Platinum Binding Sites List in 5ihg
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound I, A Platin(II) Compound Containing A O, S Bidentate Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:33.5
occ:0.40
O A:HOH426 2.0 26.2 0.4
O A:HOH390 2.1 23.5 0.4
ND1 A:HIS15 2.2 33.6 1.0
O A:HOH370 2.3 16.8 0.4
CG A:HIS15 3.1 29.3 1.0
CE1 A:HIS15 3.2 33.2 1.0
CB A:HIS15 3.4 25.9 1.0
CA A:HIS15 3.5 29.4 1.0
O A:HIS15 4.1 31.2 1.0
O A:HOH309 4.2 50.8 1.0
NE2 A:HIS15 4.3 31.7 1.0
CD2 A:HIS15 4.3 29.9 1.0
C A:HIS15 4.3 28.0 1.0
CG2 A:THR89 4.4 33.1 1.0
N A:HIS15 4.6 27.4 1.0
OD1 A:ASN93 4.7 49.9 1.0
OG1 A:THR89 4.8 29.4 1.0
O A:ARG14 4.9 32.9 1.0

Reference:

J.Hildebrandt, N.Hafner, H.Gorls, D.Kritsch, G.Ferraro, M.Durst, I.B.Runnebaum, A.Merlino, W.Weigand. Platinum(II) O,S Complexes As Potential Metallodrugs Against Cisplatin Resistance. Dalton Trans V. 45 18876 2016.
ISSN: ESSN 1477-9234
PubMed: 27897281
DOI: 10.1039/C6DT01388K
Page generated: Thu Oct 10 11:36:45 2024

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