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Platinum in PDB 5ii3: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ii3 was solved by G.Ferraro, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.30 / 1.78
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 78.206, 78.206, 37.005, 90.00, 90.00, 90.00
R / Rfree (%) 15.3 / 19

Other elements in 5ii3:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand (pdb code 5ii3). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ii3:

Platinum binding site 1 out of 1 in 5ii3

Go back to Platinum Binding Sites List in 5ii3
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 3, A Platin(II) Compound Containing A O, S Bidentate Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:34.5
occ:0.40
 PT1 A:6B6202 0.0 34.5 0.4
O1 A:6B6202 2.0 28.9 0.4
O3 A:6B6202 2.1 25.1 0.4
O2 A:6B6202 2.3 18.4 0.4
ND1 A:HIS15 2.3 26.9 1.0
CG A:HIS15 3.2 21.2 1.0
O A:HOH301 3.2 29.3 0.4
CE1 A:HIS15 3.4 24.4 1.0
CB A:HIS15 3.4 20.2 1.0
O A:HOH376 3.5 42.5 1.0
CA A:HIS15 3.5 19.8 1.0
O A:HIS15 4.1 20.4 1.0
O A:HOH366 4.2 32.3 0.4
C A:HIS15 4.2 19.2 1.0
O A:HOH305 4.3 59.6 1.0
O A:HOH338 4.3 33.9 1.0
CD2 A:HIS15 4.4 22.1 1.0
NE2 A:HIS15 4.4 25.2 1.0
CG2 A:THR89 4.5 21.7 1.0
OD1 A:ASN93 4.6 34.5 1.0
N A:HIS15 4.7 18.9 1.0
O A:ARG14 4.8 22.2 1.0
OG1 A:THR89 4.9 19.6 1.0

Reference:

J.Hildebrandt, N.Hafner, H.Gorls, D.Kritsch, G.Ferraro, M.Durst, I.B.Runnebaum, A.Merlino, W.Weigand. Platinum(II) O,S Complexes As Potential Metallodrugs Against Cisplatin Resistance. Dalton Trans V. 45 18876 2016.
ISSN: ESSN 1477-9234
PubMed: 27897281
DOI: 10.1039/C6DT01388K
Page generated: Thu Oct 10 11:36:46 2024

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