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Platinum in PDB 5ilc: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilc was solved by A.Merlino, G.Ferraro, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.74 / 1.75
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.407, 77.407, 37.347, 90.00, 90.00, 90.00
R / Rfree (%) 15.8 / 21.1

Other elements in 5ilc:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand also contains other interesting chemical elements:

Chlorine (Cl) 5 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand (pdb code 5ilc). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilc:

Platinum binding site 1 out of 1 in 5ilc

Go back to Platinum Binding Sites List in 5ilc
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme A Compound 2, A Platin(II) Compound Containing A O, S Bidentate Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt201

b:43.9
occ:0.30
O A:HOH430 2.0 32.1 0.3
O A:HOH401 2.1 39.5 0.3
O A:HOH369 2.3 24.9 0.3
ND1 A:HIS15 2.4 33.9 1.0
CE1 A:HIS15 3.3 31.3 1.0
CG A:HIS15 3.4 25.7 1.0
CB A:HIS15 3.6 23.0 1.0
CA A:HIS15 3.7 23.8 1.0
O A:HIS15 4.1 24.9 1.0
O A:HOH402 4.2 56.6 1.0
O A:HOH329 4.2 51.5 1.0
C A:HIS15 4.4 23.5 1.0
CG2 A:THR89 4.5 28.4 1.0
NE2 A:HIS15 4.5 30.2 1.0
CD2 A:HIS15 4.5 28.9 1.0
OD1 A:ASN93 4.6 38.3 1.0
N A:HIS15 4.8 23.3 1.0
OG1 A:THR89 4.8 24.0 1.0
O A:ARG14 5.0 28.3 1.0

Reference:

J.Hildebrandt, N.Hafner, H.Gorls, D.Kritsch, G.Ferraro, M.Durst, I.B.Runnebaum, A.Merlino, W.Weigand. Platinum(II) O,S Complexes As Potential Metallodrugs Against Cisplatin Resistance. Dalton Trans V. 45 18876 2016.
ISSN: ESSN 1477-9234
PubMed: 27897281
DOI: 10.1039/C6DT01388K
Page generated: Wed Dec 16 02:05:19 2020

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