Atomistry » Platinum » PDB 5djl-5t7l » 5ilf
Atomistry »
  Platinum »
    PDB 5djl-5t7l »
      5ilf »

Platinum in PDB 5ilf: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilf was solved by A.Merlino, G.Ferraro, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.14 / 1.85
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.983, 77.983, 37.281, 90.00, 90.00, 90.00
R / Rfree (%) 16.7 / 23.3

Other elements in 5ilf:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand (pdb code 5ilf). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilf:

Platinum binding site 1 out of 1 in 5ilf

Go back to Platinum Binding Sites List in 5ilf
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:50.5
occ:0.30
 O A:HOH426 2.0 41.5 0.3
O A:HOH403 2.0 42.3 0.3
O A:HOH375 2.3 28.8 0.3
ND1 A:HIS15 2.5 28.3 1.0
CG A:HIS15 3.3 26.1 1.0
CB A:HIS15 3.4 26.4 1.0
CA A:HIS15 3.5 26.3 1.0
CE1 A:HIS15 3.6 28.6 1.0
O A:HOH394 3.6 43.2 1.0
O A:HIS15 4.1 27.8 1.0
O A:HOH320 4.1 42.0 1.0
C A:HIS15 4.2 23.3 1.0
CG2 A:THR89 4.3 25.6 1.0
CD2 A:HIS15 4.5 25.3 1.0
NE2 A:HIS15 4.6 26.8 1.0
N A:HIS15 4.7 28.0 1.0
OG1 A:THR89 4.8 23.0 1.0
OD1 A:ASN93 4.8 35.8 1.0
O A:ARG14 4.9 34.1 1.0

Reference:

J.Hildebrandt, N.Hafner, H.Gorls, D.Kritsch, G.Ferraro, M.Durst, I.B.Runnebaum, A.Merlino, W.Weigand. Platinum(II) O,S Complexes As Potential Metallodrugs Against Cisplatin Resistance. Dalton Trans V. 45 18876 2016.
ISSN: ESSN 1477-9234
PubMed: 27897281
DOI: 10.1039/C6DT01388K
Page generated: Wed Dec 16 02:05:19 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy