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Platinum in PDB 5ilf: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilf was solved by A.Merlino, G.Ferraro, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 55.14 / 1.85
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 77.983, 77.983, 37.281, 90.00, 90.00, 90.00
R / Rfree (%) 16.7 / 23.3

Other elements in 5ilf:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand also contains other interesting chemical elements:

Chlorine (Cl) 4 atoms
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand (pdb code 5ilf). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand, PDB code: 5ilf:

Platinum binding site 1 out of 1 in 5ilf

Go back to Platinum Binding Sites List in 5ilf
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Compound 4, A Platin(II) Compound Containing A O, S Bidentate Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt202

b:50.5
occ:0.30
 O A:HOH426 2.0 41.5 0.3
O A:HOH403 2.0 42.3 0.3
O A:HOH375 2.3 28.8 0.3
ND1 A:HIS15 2.5 28.3 1.0
CG A:HIS15 3.3 26.1 1.0
CB A:HIS15 3.4 26.4 1.0
CA A:HIS15 3.5 26.3 1.0
CE1 A:HIS15 3.6 28.6 1.0
O A:HOH394 3.6 43.2 1.0
O A:HIS15 4.1 27.8 1.0
O A:HOH320 4.1 42.0 1.0
C A:HIS15 4.2 23.3 1.0
CG2 A:THR89 4.3 25.6 1.0
CD2 A:HIS15 4.5 25.3 1.0
NE2 A:HIS15 4.6 26.8 1.0
N A:HIS15 4.7 28.0 1.0
OG1 A:THR89 4.8 23.0 1.0
OD1 A:ASN93 4.8 35.8 1.0
O A:ARG14 4.9 34.1 1.0

Reference:

J.Hildebrandt, N.Hafner, H.Gorls, D.Kritsch, G.Ferraro, M.Durst, I.B.Runnebaum, A.Merlino, W.Weigand. Platinum(II) O,S Complexes As Potential Metallodrugs Against Cisplatin Resistance. Dalton Trans V. 45 18876 2016.
ISSN: ESSN 1477-9234
PubMed: 27897281
DOI: 10.1039/C6DT01388K
Page generated: Thu Oct 10 11:37:06 2024

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