Atomistry » Platinum » PDB 5djm-5v6i » 5nj1
Atomistry »
  Platinum »
    PDB 5djm-5v6i »
      5nj1 »

Platinum in PDB 5nj1: The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1

Enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1

All present enzymatic activity of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1:
3.2.1.17;

Protein crystallography data

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1, PDB code: 5nj1 was solved by G.Ferraro, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 56.22 / 1.85
Space group P 43 21 2
Cell size a, b, c (Å), α, β, γ (°) 79.512, 79.512, 35.906, 90.00, 90.00, 90.00
R / Rfree (%) 18.2 / 24.2

Other elements in 5nj1:

The structure of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1 also contains other interesting chemical elements:

Arsenic (As) 1 atom
Sodium (Na) 1 atom

Platinum Binding Sites:

The binding sites of Platinum atom in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1 (pdb code 5nj1). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1, PDB code: 5nj1:

Platinum binding site 1 out of 1 in 5nj1

Go back to Platinum Binding Sites List in 5nj1
Platinum binding site 1 out of 1 in the The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Adduct Formed in the Reaction Between Hen Egg White Lysozyme and Arsenoplatin-1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt208

b:24.3
occ:0.60
 PT1 A:A6R208 0.0 24.3 0.6
N1 A:A6R208 2.0 29.7 0.6
N2 A:A6R208 2.0 25.9 0.6
NE2 A:HIS15 2.1 32.8 1.0
AS1 A:A6R208 2.2 25.6 0.6
C1 A:A6R208 2.9 30.4 0.6
C3 A:A6R208 2.9 28.1 0.6
CE1 A:HIS15 3.0 36.3 1.0
O1 A:A6R208 3.0 27.7 0.6
O2 A:A6R208 3.1 23.0 0.6
OG1 A:THR89 3.2 37.9 1.0
CD2 A:HIS15 3.2 32.5 1.0
O3 A:A6R208 3.6 25.5 0.6
O4 A:A6R208 3.6 27.5 0.6
NE A:ARG14 3.7 48.2 1.0
NH2 A:ARG14 3.9 42.8 1.0
CZ A:ARG14 3.9 45.5 1.0
OD1 A:ASP87 3.9 39.2 1.0
O A:HOH315 3.9 49.1 1.0
ND1 A:HIS15 4.1 37.2 1.0
CG A:HIS15 4.2 35.0 1.0
C2 A:A6R208 4.3 32.2 0.6
C4 A:A6R208 4.3 29.4 0.6
OD2 A:ASP87 4.3 40.9 1.0
O A:HOH337 4.4 31.5 0.6
CG A:ASP87 4.5 43.0 1.0
NH1 A:ARG14 4.5 37.2 1.0
CD A:ARG14 4.6 46.5 1.0
CB A:THR89 4.6 35.0 1.0
CG A:ARG14 4.9 46.6 1.0

Reference:

D.Miodragovic, A.Merlino, E.P.Swindell, A.Bogachkov, R.W.Ahn, S.Abuhadba, G.Ferraro, T.Marzo, A.P.Mazar, L.Messori, T.V.O'halloran. Arsenoplatin-1 Is A Dual Pharmacophore Anticancer Agent. J.Am.Chem.Soc. V. 141 6453 2019.
ISSN: ESSN 1520-5126
PubMed: 30943017
DOI: 10.1021/JACS.8B13681
Page generated: Thu Oct 10 11:39:47 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy