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Platinum in PDB 5t7l: Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1

Enzymatic activity of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1

All present enzymatic activity of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1:
3.6.3.54;

Protein crystallography data

The structure of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1, PDB code: 5t7l was solved by R.Caliandro, V.Mirabelli, R.Caliandro, A.Rosato, A.Lasorsa, A.Galliani, F.Arnesano, G.Natile, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.49 / 2.83
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 47.617, 54.659, 63.719, 90.00, 90.00, 90.00
R / Rfree (%) 20 / 27.3

Other elements in 5t7l:

The structure of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1 also contains other interesting chemical elements:

Copper (Cu) 2 atoms

Platinum Binding Sites:

The binding sites of Platinum atom in the Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1 (pdb code 5t7l). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1, PDB code: 5t7l:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in 5t7l

Go back to Platinum Binding Sites List in 5t7l
Platinum binding site 1 out of 2 in the Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt101

b:93.1
occ:0.72
SG B:CYS15 2.3 68.0 0.7
CB A:CYS12 2.4 18.4 0.3
CB A:CYS12 2.7 47.5 0.7
CB B:CYS15 2.7 58.8 0.3
CB B:CYS15 2.7 62.7 0.7
SG A:CYS12 2.8 62.0 0.7
SG B:CYS15 3.1 56.6 0.3
CA A:CYS12 3.5 49.5 0.7
CA A:CYS12 3.5 35.7 0.3
SG A:CYS12 3.6 8.4 0.3
CU A:CU104 3.9 22.7 0.3
CA B:CYS15 4.2 62.8 0.3
CA B:CYS15 4.2 61.7 0.7
N A:CYS12 4.3 47.5 0.3
N A:CYS12 4.3 56.0 0.7
N B:CYS15 4.6 68.5 0.3
N B:CYS15 4.6 68.8 0.7
C A:CYS12 4.6 42.2 0.3
C A:CYS12 4.6 48.7 0.7
N A:GLY13 4.7 48.4 1.0
OG1 B:THR14 4.8 81.8 1.0
OG B:SER17 4.8 92.2 1.0
CG2 A:THR11 4.8 53.9 1.0
O A:THR11 4.9 50.9 1.0
C A:THR11 4.9 56.3 1.0

Platinum binding site 2 out of 2 in 5t7l

Go back to Platinum Binding Sites List in 5t7l
Platinum binding site 2 out of 2 in the Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Pt(II)-Mediated Copper-Dependent Interactions Between ATOX1 and MNK1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Pt103

b:0.0
occ:0.36
CE A:LYS3 2.3 90.3 1.0
NZ A:LYS3 2.4 86.5 1.0
O A:HOH202 2.5 43.6 1.0
SG A:CYS41 2.7 59.9 1.0
CD A:LYS3 2.8 88.2 1.0
O A:HOH204 3.1 31.8 0.9
CG A:LYS3 3.7 80.8 1.0
CB A:CYS41 3.7 53.7 1.0
CB A:LYS3 4.8 75.7 1.0
OE2 A:GLU5 4.9 97.4 1.0

Reference:

A.Lasorsa, M.I.Nardella, A.Rosato, V.Mirabelli, R.Caliandro, R.Caliandro, G.Natile, F.Arnesano. Mechanistic and Structural Basis For Inhibition of Copper Trafficking By Platinum Anticancer Drugs. J.Am.Chem.Soc. V. 141 12109 2019.
ISSN: ESSN 1520-5126
PubMed: 31283225
DOI: 10.1021/JACS.9B05550
Page generated: Wed Dec 16 02:05:24 2020

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