Platinum in PDB 6hjt: The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage

The structure of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage, PDB code: 6hjt was solved by A.Pica, G.Ferraro, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	19.30 / 1.33
Space group	F 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	181.156, 181.156, 181.156, 90.00, 90.00, 90.00
R / Rfree (%)	12.7 / 15.7

The structure of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage also contains other interesting chemical elements:

Cadmium	(Cd)	7 atoms
Chlorine	(Cl)	4 atoms

The binding sites of Platinum atom in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage (pdb code 6hjt). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 5 binding sites of Platinum where determined in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage, PDB code: 6hjt:
Jump to Platinum binding site number: 1; 2; 3; 4; 5;

Platinum binding site 1 out of 5 in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt210 b:48.8 occ:0.30 O A:HOH304 2.0 50.7 0.3 O A:HOH474 2.1 46.2 0.3 NE2 A:HIS49 2.1 42.2 1.0 O A:HOH527 2.1 54.7 0.3 CD2 A:HIS49 2.9 41.8 1.0 CE1 A:HIS49 3.3 30.4 1.0 O A:HOH525 4.0 79.4 1.0 CG A:HIS49 4.1 39.0 1.0 CG A:GLU53 4.2 19.9 0.5 ND1 A:HIS49 4.3 58.7 1.0 CD A:GLU53 4.6 27.6 0.5 OE1 A:GLU53 4.9 53.2 0.5

Platinum binding site 2 out of 5 in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt211 b:34.9 occ:0.35 O A:HOH378 1.7 27.5 0.3 O A:HOH311 1.9 22.4 0.3 O A:HOH519 2.0 40.4 0.3 ND1 A:HIS132 2.0 38.7 1.0 CE1 A:HIS132 3.0 53.3 1.0 CG A:HIS132 3.1 32.6 1.0 CB A:HIS132 3.4 31.2 1.0 CA A:HIS132 3.6 23.1 1.0 O A:SER131 4.0 34.8 1.0 NE2 A:HIS132 4.1 60.7 1.0 CD2 A:HIS132 4.2 40.1 1.0 NE A:ARG64 4.2 45.4 0.5 O A:HIS132 4.5 25.6 1.0 CZ A:ARG64 4.5 56.9 0.5 N A:HIS132 4.5 23.5 1.0 C A:SER131 4.6 28.3 1.0 C A:HIS132 4.6 22.7 1.0 NH2 A:ARG64 4.7 75.5 0.5 CD A:ARG64 4.7 31.2 0.5 NE A:ARG64 4.8 48.7 0.6 CD A:ARG64 4.8 29.6 0.6

Platinum binding site 3 out of 5 in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt212 b:59.2 occ:0.40 O A:HOH422 1.9 42.4 0.4 ND1 A:HIS49 2.0 58.7 1.0 O A:HOH334 2.5 56.3 0.4 CL A:CL218 2.7 67.1 0.4 CE1 A:HIS49 2.9 30.4 1.0 CG A:HIS49 3.0 39.0 1.0 CB A:HIS49 3.3 18.9 1.0 NE2 A:HIS49 4.0 42.2 1.0 CD2 A:HIS49 4.0 41.8 1.0 CA A:HIS49 4.1 14.8 1.0 CD A:CD205 4.3 35.9 0.3 O A:HOH524 4.5 51.0 1.0 CL A:CL218 4.6 41.5 0.3 N A:HIS49 4.9 14.0 1.0 OE2 A:GLU45 5.0 49.5 0.5

Platinum binding site 4 out of 5 in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt213 b:61.8 occ:0.25 NE2 A:HIS132 2.0 60.7 1.0 O A:HOH438 2.0 36.7 0.2 C1 A:DMS217 2.0 32.9 0.2 S A:DMS217 2.2 20.5 0.2 CE1 A:HIS132 2.6 53.3 1.0 C2 A:DMS217 3.0 30.1 0.2 CD2 A:HIS132 3.3 40.1 1.0 O A:DMS217 3.6 35.4 0.2 ND1 A:HIS132 3.8 38.7 1.0 O A:HOH497 4.1 45.5 1.0 CG A:HIS132 4.2 32.6 1.0 CB A:SER131 4.7 33.8 1.0

Platinum binding site 5 out of 5 in the The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of The X-Ray Structure of the Horse Spleen Ferritin Nanocage Containing Pt, Obtained Upon Encapsulation of A Pt(II) Terpyridine Compound Within the Protein Cage within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt214 b:37.5 occ:0.20 NE2 A:HIS114 2.1 19.4 0.3 CE1 A:HIS114 2.3 28.1 0.7 CE1 A:HIS114 2.6 15.2 0.3 NE2 A:HIS114 2.7 29.9 0.7 O A:HOH363 2.9 29.1 0.4 OE2 A:GLU130 3.2 34.0 1.0 CB A:CYS126 3.3 25.2 1.0 SG A:CYS126 3.4 32.3 1.0 CD2 A:HIS114 3.4 19.5 0.3 ND1 A:HIS114 3.5 29.3 0.7 ND1 A:HIS114 3.8 19.6 0.3 CD2 A:HIS114 3.9 24.3 0.7 CG A:HIS114 4.2 18.4 0.3 CG A:HIS114 4.3 23.9 0.7 CD A:GLU130 4.5 40.6 1.0 CA A:CYS126 4.5 23.1 1.0 O A:HOH550 4.6 72.1 1.0 O A:HOH363 4.7 21.1 0.6 CB A:SER118 4.9 28.0 1.0

G.Ferraro, A.Pica, G.Petruk, F.Pane, A.Amoresano, A.Cilibrizzi, R.Vilar, D.M.Monti, A.Merlino. Preparation, Structure, Cytotoxicity and Mechanism of Action of Ferritin-Pt(II) Terpyridine Compound Nanocomposites. Nanomedicine (Lond) V. 13 2995 2018.
ISSN: ISSN 1748-6963
PubMed: 30501559
DOI: 10.2217/NNM-2018-0259