Platinum in PDB 6myl: The PRP8 Intein-Cisplatin Complex

The structure of The PRP8 Intein-Cisplatin Complex, PDB code: 6myl was solved by Z.Li, H.Li, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.55 / 3.06
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	74.853, 74.853, 191.886, 90.00, 90.00, 90.00
R / Rfree (%)	24.3 / 29.8

The binding sites of Platinum atom in the The PRP8 Intein-Cisplatin Complex (pdb code 6myl). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 9 binding sites of Platinum where determined in the The PRP8 Intein-Cisplatin Complex, PDB code: 6myl:
Jump to Platinum binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Platinum binding site 1 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt201 b:0.7 occ:1.00 N A:CYS1 2.2 0.7 1.0 SG A:CYS1 2.3 86.5 1.0 CB A:CYS1 2.8 80.1 1.0 CA A:CYS1 3.0 84.3 1.0 C A:ASN170 4.1 0.6 1.0 ND1 A:HIS64 4.1 83.5 1.0 O A:ASN170 4.1 0.1 1.0 C A:CYS1 4.2 74.4 1.0 OG1 A:THR61 4.3 77.1 1.0 ND2 A:ASN63 4.3 99.8 1.0 O A:CYS1 4.5 65.9 1.0 CA A:HIS64 4.5 76.0 1.0 CB A:HIS64 4.8 72.5 1.0 CG A:HIS64 4.9 84.4 1.0 CG A:ASN63 4.9 75.4 1.0 N A:HIS64 5.0 79.9 1.0 OD1 A:ASN63 5.0 73.4 1.0

Platinum binding site 2 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt202 b:0.3 occ:1.00 NE2 A:HIS62 2.2 84.8 1.0 CE1 A:HIS62 3.2 79.4 1.0 CD2 A:HIS62 3.2 85.8 1.0 OE1 A:GLU45 4.1 0.4 1.0 ND1 A:HIS62 4.3 78.2 1.0 OE2 A:GLU45 4.3 99.1 1.0 CG A:HIS62 4.4 85.7 1.0 OD1 A:ASN63 4.4 73.4 1.0 CD A:GLU45 4.6 98.7 1.0 CG A:ASN63 4.9 75.4 1.0

Platinum binding site 3 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt203 b:0.5 occ:1.00 NE2 A:HIS169 2.2 0.8 1.0 OD2 A:ASP95 2.2 0.3 1.0 CD2 A:HIS169 2.9 0.6 1.0 CE1 A:HIS169 3.2 0.0 1.0 CG A:ASP95 3.3 95.9 1.0 CG A:HIS169 4.1 85.6 1.0 CB A:ASP95 4.1 75.2 1.0 ND1 A:HIS169 4.2 87.8 1.0 OD1 A:ASP95 4.2 93.4 1.0 OG A:SER158 4.5 98.5 1.0

Platinum binding site 4 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt201 b:0.4 occ:1.00 N B:CYS1 2.2 0.9 1.0 SG B:CYS1 2.3 0.1 1.0 CB B:CYS1 2.8 0.7 1.0 O B:ASN170 2.8 0.2 1.0 CA B:CYS1 3.0 97.5 1.0 C B:ASN170 3.8 0.7 1.0 ND1 B:HIS64 4.2 97.2 1.0 C B:CYS1 4.2 95.9 1.0 ND2 B:ASN63 4.3 0.8 1.0 OG1 B:THR61 4.4 0.8 1.0 O B:CYS1 4.5 0.8 1.0 CA B:HIS64 4.6 97.0 1.0 CB B:HIS64 4.9 87.4 1.0 CG B:ASN63 5.0 0.4 1.0 CG B:HIS64 5.0 92.3 1.0

Platinum binding site 5 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt202 b:0.5 occ:1.00 NE2 B:HIS62 2.2 0.8 1.0 CE1 B:HIS62 2.7 0.7 1.0 OD1 B:ASN63 3.3 0.9 1.0 CD2 B:HIS62 3.3 0.8 1.0 CG B:ASN63 3.5 0.4 1.0 CB B:ASN63 3.8 0.1 1.0 ND1 B:HIS62 3.8 0.5 1.0 ND2 B:ASN63 4.0 0.8 1.0 CG B:HIS62 4.2 1.0 1.0 N B:ASN63 4.8 0.9 1.0 CA B:ASN63 4.9 0.6 1.0 OE1 B:GLU45 5.0 0.2 1.0

Platinum binding site 6 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 6 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt203 b:0.7 occ:1.00 NE2 B:HIS169 2.2 0.7 1.0 OD2 B:ASP95 2.2 0.5 1.0 CD2 B:HIS169 2.7 0.3 1.0 CG B:ASP95 3.3 0.9 1.0 CE1 B:HIS169 3.4 0.6 1.0 OG B:SER158 3.8 0.3 1.0 CG B:HIS169 3.9 0.9 1.0 OD1 B:ASP95 4.0 0.9 1.0 ND1 B:HIS169 4.3 0.6 1.0 CB B:ASP95 4.3 93.0 1.0 O B:ASP157 4.4 97.4 1.0 NH2 B:ARG93 4.5 0.5 1.0 CD2 B:LEU159 4.7 89.3 1.0

Platinum binding site 7 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 7 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Pt201 b:0.2 occ:1.00 N C:CYS1 2.2 0.5 1.0 SG C:CYS1 2.2 0.8 1.0 CB C:CYS1 2.9 0.6 1.0 CA C:CYS1 3.1 92.4 1.0 O C:ASN170 4.0 0.3 1.0 C C:ASN170 4.0 0.5 1.0 C C:CYS1 4.3 87.8 1.0 ND2 C:ASN63 4.5 0.2 1.0 ND1 C:HIS64 4.5 95.1 1.0 OG1 C:THR61 4.6 96.0 1.0 O C:CYS1 4.7 83.0 1.0 CA C:GLY151 5.0 91.1 1.0

Platinum binding site 8 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 8 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Pt202 b:0.8 occ:1.00 NE2 C:HIS62 2.2 1.0 1.0 CE1 C:HIS62 2.6 1.0 1.0 CD2 C:HIS62 3.5 0.4 1.0 ND1 C:HIS62 3.9 0.5 1.0 OD1 C:ASN63 3.9 0.6 1.0 CG C:ASN63 4.0 0.0 1.0 CB C:ASN63 4.2 0.3 1.0 CG C:HIS62 4.3 98.6 1.0 ND2 C:ASN63 4.5 0.2 1.0

Platinum binding site 9 out of 9 in the The PRP8 Intein-Cisplatin Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 9 of The PRP8 Intein-Cisplatin Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Pt203 b:0.8 occ:1.00 OD2 C:ASP95 2.2 98.2 1.0 NE2 C:HIS169 2.2 0.0 1.0 CD2 C:HIS169 2.9 0.4 1.0 CG C:ASP95 3.3 0.1 1.0 CE1 C:HIS169 3.4 0.8 1.0 OD1 C:ASP95 4.0 0.1 1.0 OG C:SER158 4.1 0.6 1.0 CG C:HIS169 4.2 0.2 1.0 CB C:ASP95 4.2 88.2 1.0 ND1 C:HIS169 4.3 0.1 1.0 O C:ASP157 4.6 0.9 1.0 NH2 C:ARG93 4.7 0.6 1.0

Z.Li, B.Fu, C.M.Green, Y.Lang, T.S.Owen, J.Zhang, X.Li, B.P.Callahan, S.Chaturvedi, M.Belfort, H.Li. Cisplatin Inhibits PRP8 Intein Splicing and Protects Mice From Challenge of Cryptococcus Neoformans To Be Published.