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Atomistry » Platinum » PDB 5v6i-7bd7 » 6wx5 » |
Platinum in PDB 6wx5: Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with HewlEnzymatic activity of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl
All present enzymatic activity of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl:
3.2.1.17; Protein crystallography data
The structure of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl, PDB code: 6wx5
was solved by
M.P.Sullivan,
C.G.Hartinger,
D.C.Goldstone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6wx5:
The structure of Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl also contains other interesting chemical elements:
Platinum Binding Sites:
The binding sites of Platinum atom in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl
(pdb code 6wx5). This binding sites where shown within
5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl, PDB code: 6wx5: Platinum binding site 1 out of 1 in 6wx5Go back to![]() ![]()
Platinum binding site 1 out
of 1 in the Adducts Formed After 3 Weeks in the Reaction of Chlorido[Chlorido(2, 2'-((2-([2,2':6',2''-Terpyridin]-4'-Yloxy)Ethyl)Azanediyl)Bis(Ethan- 1-Ol))Platinum(II)] with Hewl
![]() Mono view ![]() Stereo pair view
Reference:
M.Adams,
M.P.Sullivan,
K.K.H.Tong,
D.C.Goldstone,
M.Hanif,
S.M.F.Jamieson,
C.G.Hartinger.
Mustards-Derived Terpyridine-Platinum Complexes As Anticancer Agents: Dna Alkylation Vs Coordination. Inorg.Chem. 2021.
Page generated: Wed Mar 3 15:42:48 2021
ISSN: ISSN 0020-1669 PubMed: 33497565 DOI: 10.1021/ACS.INORGCHEM.0C03317 |
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