Platinum in PDB 1qyy: Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution

The structure of Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution, PDB code: 1qyy was solved by K.I.Varughese, Z.M.Ruggeri, R.Celikel, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	15.00 / 2.80
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	51.610, 113.820, 56.210, 90.00, 95.21, 90.00
R / Rfree (%)	21.9 / 28.2

The binding sites of Platinum atom in the Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution (pdb code 1qyy). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 3 binding sites of Platinum where determined in the Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution, PDB code: 1qyy:
Jump to Platinum binding site number: 1; 2; 3;

Platinum binding site 1 out of 3 in the Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt505 b:30.0 occ:1.00 NE2 A:HIS86 2.3 28.3 1.0 CE1 A:HIS86 2.8 28.3 1.0 CE1 A:PHE109 3.5 23.6 1.0 CD1 A:PHE109 3.5 23.6 1.0 CD2 A:HIS86 3.6 28.3 1.0 ND1 A:HIS86 4.1 28.3 1.0 CG A:HIS86 4.5 28.3 1.0 CZ A:PHE109 4.5 23.6 1.0 CG A:PHE109 4.6 23.6 1.0 CG G:PRO260 4.7 52.3 1.0 CE2 G:PHE254 4.7 38.5 1.0

Platinum binding site 2 out of 3 in the Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt506 b:27.7 occ:1.00 O A:HOH507 2.4 10.8 1.0 ND1 A:HIS195 2.5 42.2 1.0 CG A:HIS195 2.9 42.2 1.0 CB A:HIS195 3.0 42.2 1.0 CA A:HIS195 3.4 48.3 1.0 CE1 A:HIS195 3.4 42.2 1.0 CA A:GLU172 3.6 50.0 1.0 O A:GLU172 3.6 50.0 1.0 CB A:GLU172 3.7 42.9 1.0 CD2 A:HIS195 3.9 42.2 1.0 C A:GLU172 4.0 50.0 1.0 NE2 A:HIS195 4.2 42.2 1.0 N A:LEU196 4.2 44.1 1.0 C A:HIS195 4.4 48.3 1.0 N A:HIS195 4.4 48.3 1.0 O A:LEU171 4.8 36.4 1.0 N A:GLU172 4.9 50.0 1.0 CG A:GLU172 4.9 42.9 1.0

Platinum binding site 3 out of 3 in the Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of N-Terminal Domain of Human Platelet Receptor Glycoprotein Ib-Alpha at 2.8 Angstrom Resolution within 5.0Å range: probe atom residue distance (Å) B Occ G:Pt602 b:31.0 occ:1.00 NE2 G:HIS86 2.2 25.1 1.0 CD2 G:HIS86 3.2 25.1 1.0 CE1 G:HIS86 3.2 25.1 1.0 CE1 G:PHE109 3.5 28.8 1.0 CD1 G:PHE109 3.6 28.8 1.0 ND1 G:HIS86 4.3 25.1 1.0 CG G:HIS86 4.3 25.1 1.0 CZ G:PHE109 4.4 28.8 1.0 CG G:PHE109 4.6 28.8 1.0

K.I.Varughese, Z.M.Ruggeri, R.Celikel. Platinum-Induced Space-Group Transformation in Crystals of the Platelet Glycoprotein Ib Alpha N-Terminal Domain. Acta Crystallogr.,Sect.D V. 60 405 2004.
ISSN: ISSN 0907-4449
PubMed: 14993663
DOI: 10.1107/S0907444903026805