Platinum in PDB 4ppo: First Crystal Structure For An Oxaliplatin-Protein Complex

All present enzymatic activity of First Crystal Structure For An Oxaliplatin-Protein Complex:
3.2.1.17;

The structure of First Crystal Structure For An Oxaliplatin-Protein Complex, PDB code: 4ppo was solved by L.Messori, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	54.48 / 1.73
Space group	P 43 21 2
Cell size a, b, c (Å), α, β, γ (°)	77.049, 77.049, 37.287, 90.00, 90.00, 90.00
R / Rfree (%)	18 / 23.5

The binding sites of Platinum atom in the First Crystal Structure For An Oxaliplatin-Protein Complex (pdb code 4ppo). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total only one binding site of Platinum was determined in the First Crystal Structure For An Oxaliplatin-Protein Complex, PDB code: 4ppo:

Platinum binding site 1 out of 1 in the First Crystal Structure For An Oxaliplatin-Protein Complex


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of First Crystal Structure For An Oxaliplatin-Protein Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt210 b:48.3 occ:0.70 PT A:1PT210 0.0 48.3 0.7 O A:HOH301 2.0 34.6 0.7 N2 A:1PT210 2.0 35.2 0.7 OD2 A:ASP119 2.0 45.2 0.7 OD2 A:ASP119 2.1 35.0 0.3 N1 A:1PT210 2.1 40.3 0.7 C2 A:1PT210 2.8 41.1 0.7 CG A:ASP119 2.8 31.1 0.3 C1 A:1PT210 2.9 39.4 0.7 CG A:ASP119 2.9 34.8 0.7 OD1 A:ASP119 3.0 33.6 0.3 OD1 A:ASP119 3.0 34.2 0.7 CB A:ASP119 4.2 30.5 0.3 C3 A:1PT210 4.2 42.4 0.7 C6 A:1PT210 4.2 40.1 0.7 CB A:ASP119 4.3 32.9 0.7 OE1 A:GLN121 4.6 76.6 1.0 CB A:GLN121 4.7 40.8 1.0 CG A:GLN121 4.8 53.8 1.0

L.Messori, T.Marzo, A.Merlino. The X-Ray Structure of the Complex Formed in the Reaction Between Oxaliplatin and Lysozyme. Chem.Commun.(Camb.) V. 50 8360 2014.
ISSN: ISSN 1359-7345
PubMed: 24943911
DOI: 10.1039/C4CC02254H